Perfusion preservation versus static preservation for cardiac transplantation: effects on myocardial function and metabolism

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
David H RosenbaumMichael E Jessen

Abstract

Continuous perfusion of donor hearts for transplantation has received increasing interest, but the effects on cellular metabolism, myocyte necrosis, and myocardial edema are not well defined. Pig hearts were instrumented with sonomicrometry crystals and left ventricular catheters. Left ventricular function was quantified by the pre-load-recruitable stroke work (PRSW) relationship. Hearts were arrested with Celsior solution with 5.5 mM 13C-glucose added, and removed and stored in cold solution (n = 4) or placed in a device providing continuous perfusion of this solution at 10 ml/100 g/min (n = 4). After 4 hours of storage, left atrial samples were frozen, extracted, and analyzed by magnetic resonance spectroscopy. Hearts were then transplanted into recipient pigs and reperfused for 6 hours, with function measured hourly. At the end of the experiment, left ventricular water content and serum creatine kinase-MB isoenzyme levels were measured. Baseline left ventricular function was similar in both groups. During reperfusion, the volume-axis intercept of the PRSW relationship was significantly lower in hearts stored with continuous perfusion (p < 0.05), suggesting reduced contractile impairment. Magnetic resonance spectroscopy revea...Continue Reading

References

May 22, 1998·The Annals of Thoracic Surgery·D K NicklessF L Rosenfeldt
Nov 7, 1998·The Journal of Thoracic and Cardiovascular Surgery·W H HassaneinS F Khuri
Oct 21, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·K OshimaK Matsumoto
Oct 7, 2004·The Annals of Thoracic Surgery·Robert S PostonBartley P Griffith
Aug 8, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David O TaylorUNKNOWN International Society for Heart and Lung Transplantation

❮ Previous
Next ❯

Citations

Mar 22, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Danai BalfoussiaVassilios Papalois
Jul 12, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Evan P Kransdorf, Josef Stehlik
Dec 3, 2014·The Annals of Thoracic Surgery·Sarah M BrantMatthias Peltz
Jun 26, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christopher W WhiteDarren H Freed
Aug 6, 2011·The Journal of Surgical Research·Michael L CobertMichael E Jessen
Mar 25, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Matthias PeltzMichael E Jessen
Mar 17, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Satoru OsakiShunji Sano
Aug 9, 2016·Transplantation Direct·Ryuta SeguchiShojiro Yamaguchi
Jun 9, 2012·The Mount Sinai Journal of Medicine, New York·Michael J GoldsteinJames V Guarrera
May 11, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sarah BrantMatthias Peltz
Jan 16, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Xiaodong YuanStefan G Tullius
Nov 26, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Olivier Van CaenegemJean-Louis Vanoverschelde
Feb 18, 2016·Scandinavian Cardiovascular Journal : SCJ·Stig SteenTrygve Sjöberg
Mar 20, 2014·The Journal of Thoracic and Cardiovascular Surgery·Michael L CobertMatthias Peltz
Dec 30, 2014·Interactive Cardiovascular and Thoracic Surgery·Sarkis M MinasianTimur D Vlasov
Oct 1, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Olivier Van CaenegemJean-Louis Vanoverschelde
Jul 12, 2008·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Andrew L RivardRanjit John
Feb 27, 2015·Current Opinion in Organ Transplantation·Fadwa AliDavid C Cronin
Nov 1, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Michael L CobertMatthias Peltz
Dec 9, 2008·Current Opinion in Organ Transplantation·Michael L CobertMichael E Jessen
Feb 4, 2010·Current Opinion in Organ Transplantation·Dirk Van Raemdonck
Feb 4, 2010·Current Opinion in Organ Transplantation·Steven JacobsBart Meyns
Dec 21, 2012·Current Opinion in Organ Transplantation·Dirk Van RaemdonckJacques Pirenne
Sep 19, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Zhibin HuXiaohua Pan
Jan 29, 2011·Bulletin of Mathematical Biology·Taesoo JangJeehyun Lee
Mar 2, 2018·European Journal of Endocrinology·Gisah Amaral de CarvalhoHans Graf
Mar 1, 2018·Frontiers in Cardiovascular Medicine·Christopher W WhiteDarren H Freed
May 7, 2020·Current Opinion in Organ Transplantation·Arjun Iyer, Kumud Dhital
Sep 16, 2020·International Journal of Molecular Sciences·Mindaugas KvietkauskasPeter Schemmer
Dec 1, 2020·The Journal of Surgical Research·Cyonna HolmesMichael E Jessen
May 7, 2020·Current Opinion in Organ Transplantation·Arjun Iyer, Kumud Dhital

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

The Journal of Surgical Research
David H RosenbaumMichael E Jessen
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Michael J CollinsRobert S Poston
Transplant International : Official Journal of the European Society for Organ Transplantation
Fan ZhangHui Lin
© 2021 Meta ULC. All rights reserved