Perfusion quantification using dynamic contrast-enhanced ultrasound: the impact of dynamic range and gain on time-intensity curves

Ultrasonics
Thomas GauthierE Leen

Abstract

The objective of this study was to assess the impact of dynamic range and gain on perfusion quantification using linearized log-compressed data. An indicator-dilution experiment was developed with an in vitro flow phantom setup used with SonoVue contrast agent (Bracco SpA, Milan, Italy). Imaging was performed with a Philips iU22 scanner and a C5-1 curvilinear transducer using a contrast-specific nonlinear pulse sequence (power modulation) at 1.7MHz. Clinical dynamic contrast-enhanced ultrasound image loops of liver tumors were also collected for preliminary validation of the in vitro findings. Time-intensity curves were extracted from image loops with two different approaches: from linearized log-compressed data and from linear (uncompressed) data. The error of time-intensity curve parameters derived from linearized log-compressed data (deviation from linear data) was found to be less than 2.1% and 5.4% for all studied parameters in the in vitro experiment and in the clinical study, respectively, when a high dynamic range setting (at least 50dB on the iU22) is used. The gain must be carefully adjusted to ensure a high signal-to-noise ratio and to avoid signal saturation. From the time-intensity curve analysis it was also found ...Continue Reading

References

Aug 25, 2001·European Radiology·D CosgroveC Harvey
Sep 13, 2003·Ultrasound Quarterly·Michalakis AverkiouSeth Jensen
Aug 10, 2004·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·T AlbrechtUNKNOWN EFSUMB Study Group
Oct 1, 2004·The British Journal of Radiology·G M Tozer
Oct 14, 2004·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Massimo MischiErik H Korsten
Feb 9, 2005·European Radiology·Patrick Phillips, Edward Gardner
Jul 19, 2006·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Marcel ArditiNicolas G Rognin
Oct 4, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Stefan Delorme, Martin Krix
Feb 14, 2008·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·M ClaudonT Whittingham
Nov 11, 2009·Ultrasound in Medicine & Biology·Michalakis AverkiouEdward Leen
Feb 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nathalie LassauBernard J Escudier
Dec 15, 2010·Ultrasound in Medicine & Biology·Vassilis SborosA S McNeilly

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Citations

Mar 21, 2013·Investigative Radiology·Jean-Marc HyvelinFrançois Tranquart
Sep 21, 2013·Journal of Ultrasound·R StramareL Rubaltelli
Jul 25, 2013·Ultrasound in Medicine & Biology·Thomas PayenS Lori Bridal
May 1, 2015·European Radiology·Damianos ChristofidesMichalakis A Averkiou
Aug 9, 2011·Ultrasound in Medicine & Biology·John M HudsonPeter N Burns
Dec 1, 2015·Ultrasound in Medicine & Biology·Diya WangMingxi Wan
Mar 3, 2015·IEEE Transactions on Bio-medical Engineering·Avinoam David Bar-ZionF Stuart Foster
Oct 26, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Guillaume BarroisLori Bridal
Jan 15, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Christina P KeravnouMichalakis A Averkiou
Apr 15, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alexandre DizeuxS Lori Bridal
Feb 9, 2017·Clinical Physiology and Functional Imaging·Thomas P HeininkJohn P Williams
Jun 29, 2017·Ultrasound in Medicine & Biology·Sarah J BlackwoodStephen Rattigan
Oct 17, 2017·Journal of Veterinary Internal Medicine·E StockK Vanderperren
Sep 21, 2018·Acta Radiologica·Natalia Arteaga-MarreroDag R Olsen
Mar 5, 2019·Insights Into Imaging·Roberto García-FigueirasHerbert Alberto Vargas
Mar 1, 2012·Anesthesia and Analgesia·Carolien S E BulteR Arthur Bouwman
Jun 18, 2015·Physics in Medicine and Biology·Salvatore SaporitoMassimo Mischi
Jan 26, 2013·Physiological Measurement·Vratislav HarabisRadovan Jirik
Mar 2, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Thomas P GauthierEdward L S Leen
Aug 28, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Thomas P GauthierEdward L S Leen
Feb 17, 2015·Physics in Medicine and Biology·Guillaume BarroisS Lori Bridal
Nov 5, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Melissa VerkaikEtto C Eringa
Apr 5, 2019·European Radiology Experimental·Ángel Alberich-BayarriLuis Martí-Bonmatí
Mar 5, 2020·European Radiology Experimental·Marije E KamphuisCornelis H Slump

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