Perfusion scintigraphy in the assessment of autologous cell therapy in diabetic patients with critical limb ischemia

Physiological Research
Andrea NemcováM Buncova

Abstract

Perfusion scintigraphy with technetium-99-methoxy-isobutyl-isonitrile ((99m)Tc-MIBI) is often used for assessing myocardial function but the number of studies concerning lower limb perfusion is limited. The aim of our study was to assess whether (99m)Tc-MIBI was an eligible method for evaluation of the effect of cell therapy on critical limb ischemia (CLI) in diabetic patients. (99m)Tc-MIBI of calf muscles was performed before and 3 months after autologous cell therapy (ACT) in 24 diabetic patients with CLI. Scintigraphic parameters such as rest count and exercising count after a stress test were defined. These parameters and their ratios were compared between treated and untreated (control) limbs and with changes in transcutaneous oxygen pressure (TcPO(2)) that served as a reference method. The effect of ACT was confirmed by a significant increase in TcPO(2) values (p<0.001) at 3 months after ACT. We did not observe any significant changes of scintigraphic parameters both at rest and after stress 3 months after ACT, there were no differences between treated and control limbs and no association with TcPO(2) changes. Results of our study showed no significant contribution of (99m)Tc-MIBI of calf muscles to the assessment of ACT ...Continue Reading

References

Nov 7, 2000·Nuclear Medicine Communications·Y Z CelenM Yilmaz
May 2, 2001·Seminars in Nuclear Medicine·R M WolframH Sinzinger
May 8, 2004·European Journal of Nuclear Medicine and Molecular Imaging·S R UnderwoodUNKNOWN Royal College of Radiologists
Jun 5, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D J Collinson, R Donnelly
Sep 3, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Manish Aghi, E Antonio Chiocca
Dec 5, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L NorgrenKenneth Rosenfield
Jan 2, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L GrazianiR De Giglio
Dec 7, 2007·Vascular·Konstantinos I MakrisIraklis I Pipinos
Feb 4, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·E B JudeN Tentolouris
Feb 23, 2010·Thrombosis and Haemostasis·Holger LawallBerthold Amann
May 22, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Robert J GroplerMaria Cecilia Ziadi
Sep 10, 2010·Journal of Vascular Surgery·Frank Pomposelli
Mar 20, 2014·Current Cardiology Reports·Oliver Gaemperli
Mar 13, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·J R W BrownriggR J Hinchliffe
Mar 31, 2015·Seminars in Vascular Surgery·Erik BenitezBauer E Sumpio
Aug 25, 2015·Stem Cells International·Rita CompagnaRaffaele Serra
Sep 4, 2015·Diabetes/metabolism Research and Reviews·R J HinchliffeUNKNOWN International Working Group on the Diabetic Foot
Jul 18, 2016·Techniques in Vascular and Interventional Radiology·Anahita Dua, Cheong J Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.