Peri-adolescence isolation rearing alters social behavior and nociception in rats

Neuroscience Letters
Qingxuan MengWeiwen Wang

Abstract

Social isolation results in fundamental behavioral abnormalities in rodents which models certain neuropsychiatric disorders such as schizophrenia. However, the developmental stage that is most vulnerable to social isolation is largely unknown. In the present study, we subjected weaning rats to a four-week peri-adolescence isolation rearing (PAIR) and then returned them to social rearing for an additional four weeks until adulthood. Open field locomotion, social interaction behavior, and acute pain sensitivity were examined at different time points. PAIR rats showed moderate hyperactivity towards a novel environment, an anxiogenic-like behavioral profile, and increased aggression and social interaction behavior, the last three of which could be restored by re-socialization procedure. In addition, PAIR animals showed significantly reduced pain sensitivity even after the re-socialization period. In summary, this study advances the use of peri-adolescent isolation rearing as an animal model to study neurodevelopmental manipulation induced behavioral abnormalities.

References

Sep 1, 1965·Toxicology and Applied Pharmacology·A M HatchH C Grice
Aug 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·J P CoudereauH Frances
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Oct 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·G JonesM J Owen
May 26, 2004·Brain Research. Developmental Brain Research·Kim G C HellemansMary C Olmstead
Jan 11, 2005·Behavioural Brain Research·Therese A KostenJeansok J Kim
Nov 29, 2005·Frontiers in Neuroendocrinology·Cheryl L Sisk, Julia L Zehr
Apr 25, 2006·Psychiatry Research·Thomas JochumKarl-Jürgen Bär
Oct 4, 2006·Psychopharmacology·Axel BeckerHelmut Schröder
Sep 2, 2008·Physiology & Behavior·Gabor TubolyGyöngyi Horvath
Jun 17, 2009·Physiology & Behavior·Feng ShaoWeiwen Wang
Jul 1, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xiaohong ZhaoShuchang He

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Citations

Jan 1, 2013·Psychopharmacology·Naotaka HoriguchiToshio Matsuda
Oct 29, 2013·Pharmacology, Biochemistry, and Behavior·Naotaka HoriguchiToshio Matsuda
Jul 7, 2012·Behavioural Brain Research·Guy SandnerAyikoe Guy Mensah-Nyagan
Mar 15, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yia-Ping LiuChe-Se Tung
Jan 22, 2015·Developmental Psychobiology·Lucas CuenyaGiselle Kamenetzky
Dec 18, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Christina A Wilson, James I Koenig
Dec 18, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Paul Moser
May 10, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Peggy SchneiderMiriam Schneider
Sep 14, 2016·Behavioural Brain Research·Sharon S LanderInna Gaisler-Salomon
Jul 31, 2021·Behavioural Brain Research·Tracie A PaineCecelia Tannous-Taylor
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Faiza MumtazAhmad Reza Dehpour
Nov 28, 2021·Nature Reviews. Neuroscience·Katelyn E SadlerCheryl L Stucky

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