Peri-ictal hypoxia is related to extent of regional brain volume loss accompanying generalized tonic-clonic seizures.

Epilepsia
Luke A AllenBeate Diehl

Abstract

Hypoxia, or abnormally low blood-oxygen levels, often accompanies seizures and may elicit brain structural changes in people with epilepsy which contribute to central processes underlying sudden unexpected death in epilepsy (SUDEP). The extent to which hypoxia may be related to brain structural alterations in this patient group remains unexplored. We analyzed high-resolution T1-weighted magnetic resonance imaging (MRI) to determine brain morphometric and volumetric alterations in people with generalized tonic-clonic seizures (GTCS) recorded during long-term video-electroencephalography (VEEG), recruited from two sites (n = 22), together with data from age- and sex-matched healthy controls (n = 43). Subjects were sub-divided into those with mild/moderate (GTCS-hypox-mild/moderate, n = 12) and severe (GTCS-hypox-severe, n = 10) hypoxia, measured by peripheral oxygen saturation (SpO2 ) during VEEG. Whole-brain voxel-based morphometry (VBM) and regional volumetry were used to assess group comparisons and correlations between brain structural measurements as well as the duration and extent of hypoxia during GTCS. Morphometric and volumetric alterations appeared in association with peri-GTCS hypoxia, including volume loss in the peri...Continue Reading

References

Jan 1, 1988·Respiration Physiology·R L Martin-Body, B M Johnston
Feb 1, 1983·The Journal of Physiology·G S DawesD W Walker
Jan 1, 1980·Annals of Neurology·L W McLainJ H Allen
May 14, 1998·Neuroscience and Biobehavioral Reviews·R M HarperM P Kristensen
May 20, 1998·Journal of Neurophysiology·B J KoosL Kruger
Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A Boulant
Jun 1, 2001·Pediatric Research·M V JohnstonW Nakajima
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·M V Johnston
Jul 26, 2003·The Cerebellum·Fadi Xu, Donald T Frazier
Jan 22, 2005·Progress in Brain Research·Jennifer E SlemmerJohn T Weber
Jan 27, 2005·Neuroscience Letters·Eung-Kwon PaeRonald M Harper
Aug 15, 2006·Trends in Neurosciences·Glenda C Harris, Gary Aston-Jones
Nov 23, 2007·NeuroImage·Cynthia M StonningtonRichard S J Frackowiak
Oct 28, 2008·Brain : a Journal of Neurology·Lisa M BatemanMasud Seyal
Sep 3, 2013·NeuroImage·Hidemasa TakaoKuni Ohtomo
Jan 7, 2015·Chest·Naresh A DewanVirend K Somers
Apr 17, 2015·IEEE Transactions on Medical Imaging·M Jorge CardosoSebastien Ourselin
Aug 13, 2015·Brain : a Journal of Neurology·Britta WandschneiderBeate Diehl
Sep 22, 2015·Frontiers in Physiology·J Kevin Shoemaker, Ruma Goswami
Jan 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J KoosLawrence Kruger
Feb 28, 2017·Scientific Reports·Rocio Leal-CampanarioStephen L Macknik
Jan 18, 2018·Epilepsia·Nuria LacueySamden D Lhatoo
Aug 11, 2018·Human Brain Mapping·Susanne G MuellerAlica M Goldman
Jan 1, 2018·HSOA Trends in Anatomy and Physiology·Zheng-Quan Tang, Yong Lu

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Citations

Dec 4, 2020·Neurology·Alica M Goldman
Aug 20, 2021·Autonomic Neuroscience : Basic & Clinical·Smriti PatodiaMaria Thom
Oct 31, 2021·Nature Reviews. Neurology·Roland D ThijsRainer Surges

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