Peri-implant bone response to retrieved human zirconia oral implants after a 4-year loading period: A histologic and histomorphometric evaluation of 22 cases

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Ralf-Joachim KohalBenedikt Christopher Spies

Abstract

To evaluate the bone tissue response to surface modified zirconia oral implants retrieved from humans. Twenty-nine one-piece zirconia implants showed increased marginal bone loss and did not response to the applied peri-implantitis therapy. After their removal using a trephine bur, 22 of the implant-bone biopsies were suitable for an evaluation and immediately immersed in formalin for two weeks. Subsequent, the retrieved specimens were histologically prepared and the regions still showing osseointegration computer-assisted analyzed regarding the bone-to-implant contact (BIC) and bone density using a transmitted-light microscope. The removed implants were in situ for a mean time period of 47.7 months. After their removal, compact bone could be depicted at the apical regions. The remaining bone that was attached to the implants contained a regular lamellar structure with osteons and osteocytes. The BIC ranged from 58.1% to 93.7% (mean: 76.5%) and the bone area/density within the implant threads ranged from 57% to 97.2% (mean: 84.8%). The porous zirconia implants showed a sufficient BIC in the areas where bone still was attached. Although the implants had to be removed due to increased bone loss, it seems that the presented zircon...Continue Reading

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Citations

Sep 17, 2016·Expert Review of Medical Devices·Yen-Wei ChenJohn C Wataha
May 8, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Alireza HoushmandMike Barbeck
Sep 13, 2018·Journal of Prosthodontic Research·Hironobu NishiharaWael Att
Aug 28, 2020·Periodontology 2000·Jia-Hui Fu, Hom-Lay Wang
Mar 1, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Fernanda H SchünemannBruno Henriques

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