Peri-operative copeptin concentrations and their association with myocardial injury after vascular surgery: A prospective observational cohort study

European Journal of Anaesthesiology
Firmin KamberGiovanna Lurati Buse

Abstract

Copeptin levels in conjunction with cardiac troponin may be used to rule out early myocardial infarction in patients presenting with chest pain. Raised pre-operative copeptin has been shown to be associated with postoperative cardiac events. However, very little is known about the peri-operative time course of copeptin or the feasibility of very early postoperative copeptin measurement to diagnose or rule-out myocardial injury. In this preparatory analysis for a larger trial, we sought to examine the time course of peri-operative copeptin and identify the time at which concentrations returned to pre-operative levels. Second, in an explorative analysis, we sought to examine the association of copeptin in general and at various time points with myocardial injury occurring within the first 48 h. Preparatory analysis of a prospective, observational cohort study. Single university centre from February to July 2016. A total of 30 consecutive adults undergoing vascular surgery. Serial peri-operative copeptin measurements. We measured copeptin concentrations before and immediately after surgery (0 h), then at 2, 4, 6 and 8 h after surgery and on the first and second postoperative day. Postoperative concentrations were compared with pre...Continue Reading

References

Jun 10, 2009·Circulation·Giora LandesbergJoseph S Alpert
Jun 27, 2009·Journal of the American College of Cardiology·Tobias ReichlinChristian Mueller
Aug 28, 2009·The New England Journal of Medicine·Tobias ReichlinChristian Mueller
Dec 5, 2009·Clinical Chemistry·Evangelos GiannitsisHugo A Katus
May 8, 2010·Journal of the American College of Cardiology·Till KellerStefan Blankenberg
Apr 20, 2011·Annals of Internal Medicine·P J DevereauxUNKNOWN POISE (PeriOperative ISchemic Evaluation) Investigators
Jul 30, 2011·The American Journal of Cardiology·Rudolf JaraiHelfried Metzler
Aug 28, 2012·Circulation·Kristian ThygesenShanti Mendis
Dec 21, 2013·European Heart Journal·Christian Mueller
Feb 19, 2014·Anesthesiology·Fernando BottoUNKNOWN Vascular events In noncardiac Surgery patIents cOhort evaluatioN VISION Study Investigators
Jun 19, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Davide BolignanoCarmine Zoccali
Dec 3, 2015·The New England Journal of Medicine·P J Devereaux, Daniel I Sessler
Mar 24, 2016·Current Opinion in Anaesthesiology·Eckhard MauermannGiovanna Lurati Buse
Apr 24, 2016·The Annals of Thoracic Surgery·Andrew D Althouse
Jul 3, 2016·European Heart Journal. Acute Cardiovascular Care·Christian MuellerUNKNOWN Biomarker Study Group of the ESC Acute Cardiovascular Care Association
Nov 22, 2016·Anesthesia and Analgesia·Eckhard MauermannGiovanna Lurati Buse
Jan 21, 2017·European Journal of Anaesthesiology·Eckhard MauermannWilhelm Ruppen
Apr 27, 2017·JAMA : the Journal of the American Medical Association·UNKNOWN Writing Committee for the VISION Study InvestigatorsGordon H Guyatt

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