Peri-operative delineation of non-melanoma skin cancer margins in vivo with handheld reflectance confocal microscopy and video-mosaicking

Journal of the European Academy of Dermatology and Venereology : JEADV
E FloresMilind Rajadhyaksha

Abstract

The surgical removal of non-melanoma skin cancers (NMSCs) is guided by the pathologic examination of margins. However, the preparation of histopathology is time consuming, labour-intensive and requires separate laboratory infrastructure. Furthermore, when histopathology indicates positive margins, patients must return for re-excisions. Reflectance confocal microscopy (RCM) with a new video-mosaicking approach can noninvasively delineate margins directly on patients and potentially guide surgery in real-time, augmenting the traditional approaches of histopathology. To assess a new peri-operative RCM video-mosaicking approach for comprehensive delineation of NMSC margins on patients in vivo. Thirty-five patients undergoing Mohs micrographic surgery (MMS) in the Mohs surgery unit at Memorial Sloan Kettering Cancer Center, New York, NY were included in the study. RCM imaging was performed before and after the first staged excision by acquiring videos along the surgical margins (epidermal, peripheral and deep dermal) of each wound, which were subsequently processed into video-mosaics. Two RCM evaluators read and assessed video-mosaics, and subsequently compared to the corresponding Mohs frozen histopathology. Reflectance confocal mi...Continue Reading

References

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Citations

Apr 5, 2020·Journal of Biophotonics·Chengbo YinJonathan T C Liu
Feb 6, 2020·The British Journal of Dermatology·C Navarrete-DechentC-S J Chen
Apr 21, 2021·Photodermatology, Photoimmunology & Photomedicine·Bobyr IvanOffidani Annamaria

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