Peri-ovarian adipose tissue contributes to intraovarian control during folliculogenesis in mice

Reproduction : the Official Journal of the Society for the Study of Fertility
Liuhong YangYanhong Yu

Abstract

Peri-ovarian adipose tissue (POAT) is a kind of intra-abdominal white adipose tissue that is present surrounding the ovaries in rodents. Recent studies demonstrated that POAT-deficient mice displayed a phenotype of delayed antral follicular development, for which decreases in serum estrogen, serum FSH and FSHR levels were responsible. However, folliculogenesis is regulated by endocrine signals and also modulated by a number of locally produced intraovarian factors whose acts are both autocrine and paracrine. Here, we used a model of surgical removal of POAT unilaterally and contralateral ovaries as controls, as both were under the same endocrine control, to assess the paracrine effect of the POAT on folliculogenesis. Surgical removal of unilateral POAT resulted in delayed antral follicular development and the increased number of atretic follicles, accompanied by decreased levels of intraovarian adipokines and growth factors, lipid accumulation and steroidogenic enzyme expression. POAT-deficient ovaries displayed compensatory increased expressions of intraovarian genes, such as Vegf and Adpn for angiogenesis, Acc, Fasn, and Gapdh involved in lipogenesis and Fshr in response to FSH stimulation. Furthermore, we demonstrated that r...Continue Reading

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Citations

Jul 2, 2020·International Journal of Molecular Sciences·Eran Gershon, Nava Dekel
Jun 14, 2019·Reproductive Biology and Endocrinology : RB&E·Shweta S DipaliFrancesca E Duncan
Oct 24, 2020·Histochemistry and Cell Biology·Malgorzata GrzesiakAgnieszka Rak
Feb 18, 2021·Nature Communications·Camille BourgneufChrystèle Racine

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