Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.

PloS One
Colleen ManittCecilia Flores

Abstract

Puberty is a critical period in mesocorticolimbic dopamine (DA) system development, particularly for the medial prefrontal cortex (mPFC) projection which achieves maturity in early adulthood. The guidance cue netrin-1 organizes neuronal networks by attracting or repelling cellular processes through DCC (deleted in colorectal cancer) and UNC-5 homologue (UNC5H) receptors, respectively. We have shown that variations in netrin-1 receptor levels lead to selective reorganization of mPFC DA circuitry, and changes in DA-related behaviors, in transgenic mice and in rats. Significantly, these effects are only observed after puberty, suggesting that netrin-1 mediated effects on DA systems vary across development. Here we report on the normal expression of DCC and UNC5H in the ventral tegmental area (VTA) by DA neurons from embryonic life to adulthood, in both mice and rats. We show a dramatic and enduring pubertal change in the ratio of DCC:UNC5H receptors, reflecting a shift toward predominant UNC5H function. This shift in DCC:UNC5H ratio coincides with the pubertal emergence of UNC5H expression by VTA DA neurons. Although the distribution of DCC and UNC5H by VTA DA neurons changes during puberty, the pattern of netrin-1 immunoreactivit...Continue Reading

References

Jan 1, 1991·Physiological Reviews·M Le Moal, H Simon
Mar 1, 1988·The Journal of Comparative Neurology·A KalsbeekH B Uylings
Nov 21, 1995·Brain Research. Developmental Brain Research·M H TeicherJ C Hostetter
Oct 18, 1996·Cell·K Keino-MasuM Tessier-Lavigne
Jan 1, 1997·Journal of Psychopharmacology·M B Knable, D R Weinberger
Nov 5, 1997·Advances in Pharmacology·S R SesackA I Levey
Mar 10, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F I Tarazi, R J Baldessarini
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wenxiao LuMarina E Wolf
Nov 21, 2002·Progress in Brain Research·Colleen Manitt, Timothy E Kennedy
May 7, 2003·Neuroscience and Biobehavioral Reviews·Susan L Andersen
Jan 27, 2004·Brain Research. Developmental Brain Research·Robert Riddle, Jonathan D Pollock
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erik W DentKatherine Kalil
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-François BouchardTimothy E Kennedy
Mar 2, 2005·Molecular and Cellular Neurosciences·Ling LinOle Isacson
Jun 18, 2005·Brain Research. Brain Research Reviews·María J BarallobreEduardo Soriano
Jul 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fangjun Tang, Katherine Kalil
Mar 4, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Naofumi UesakaNobuhiko Yamamoto
Mar 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher P FordJohn T Williams

❮ Previous
Next ❯

Citations

Apr 11, 2013·Psychopharmacology·Leora YetnikoffCecilia Flores
May 28, 2014·Neuroscience Letters·Alanna GrantCecilia Flores
Apr 13, 2011·Journal of Psychiatry & Neuroscience : JPN·Cecilia Flores
May 29, 2015·The Journal of Physiology·Menglu YuanFrances M Leslie
Oct 28, 2015·FEBS Letters·Angela AndereggRajeshwar Awatramani
Oct 4, 2015·FEBS Letters·Gabriela O Bodea, Sandra Blaess
Aug 28, 2012·Trends in Molecular Medicine·Suh Youn KoKulmira Nurgali
May 26, 2015·Behavioural Brain Research·Lauren M ReynoldsCecilia Flores
Jun 7, 2013·The European Journal of Neuroscience·Meagan L AugerCecilia Flores
Oct 23, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lauren M ReynoldsCecilia Flores
Nov 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Santiago CuestaCecilia Flores
Jul 28, 2020·Frontiers in Cell and Developmental Biology·Santiago CuestaCecilia Flores
Oct 17, 2017·Trends in Neurosciences·Daniel Hoops, Cecilia Flores

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Adobe Photoshop Creative
PictureFrame

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.