Perianal Crohn's disease results in fewer pregnancies but is not exacerbated by vaginal delivery

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Amélie GrouinGuillaume Bouguen

Abstract

Despite a high prevalence of Crohn's disease in women of childbearing age, disease-related factors that may impact fertility and perianal Crohn's disease after delivery remain unclear. Self-administered questionnaires related to childbirth were completed by women with Crohn's disease referred to a single gastroenterology unit. A survival analysis was performed for statistical purposes. A total of 184 patients were assessed, including 63 nulliparous women. The cumulative probabilities of having a child were 30%, 51% and 72% at the ages of 25, 30 and 35 years, respectively. Women with colonic disease, prior abdominal surgery and perianal disease were less likely to experience childbirth. After a median follow-up of 165 weeks post-delivery, the cumulative probabilities of fistulizing perianal Crohn's disease occurrence were 8%, 12% and 21% at 1, 2 and 5 years following childbirth, respectively. Contrary to a prior history of perianal Crohn's disease and colonic location, mode of delivery was not associated with perianal fistula. An episiotomy in the group of women with prior anal lesions did not result in a higher rate of fistula recurrence. Perianal Crohn's disease is associated with fewer pregnancies, however perianal fistulas w...Continue Reading

References

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Citations

Dec 22, 2015·Gastroenterology·Geoffrey C NguyenUNKNOWN Canadian Association of Gastroenterology
Apr 21, 2017·Inflammatory Bowel Diseases·Arthur FoulonMathurin Fumery
Apr 21, 2017·Inflammatory Bowel Diseases·Kristin E BurkeAdam S Cheifetz
Apr 11, 2017·Inflammatory Bowel Diseases·Charlène BrochardGuillaume Bouguen
Jul 14, 2017·Clinical and Translational Gastroenterology·Michael ScharlLuc Biedermann
Jul 25, 2019·The Cochrane Database of Systematic Reviews·Sangmin LeeM Ellen Kuenzig
Dec 7, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S R BrownUNKNOWN ACPGBI IBD Surgery Consensus Collaboration
Dec 18, 2018·The Patient·Louise LongworthShaji Sebastian
May 29, 2021·Therapeutic Advances in Gastroenterology·Robyn LaubeRupert W Leong
Jun 15, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alessandro ArmuzziUNKNOWN Italian Group for the Study of Inflammatory Bowel Disease Working Group

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