Periapical lesions in rats with streptozotocin-induced diabetes

Journal of Endodontics
T KohsakaH Nakamura

Abstract

The purpose of this study was to investigate histologically and histometrically the changes in pulpal periapical tissues after pulpal exposure in streptozotocin-induce diabetic rats. Control rats were injected with citrate buffer. Experimental rats were injected with streptozotocin dissolved in citrate buffer. All animals received a pulpal exposure in the left mandibular first molar. Blood glucose concentration was measured at, 0, 7, 14, 28, and 42 days. All animals were killed at 7, 14, 28, and 42 days after pulpal exposure, and their mandibles were evaluated histologically and histometrically. Blood glucose levels in the experimental rats were significantly higher than those in the control rats. In experimental rats, inflammation in the apical periodontal ligament and root resorption and alveolar bone resorption were more severe than that in control rats. This study also revealed histometrically that, in experimental rats, lesions in the periapical area were significantly larger than those in control rats.

Citations

Jul 14, 2005·International Endodontic Journal·J J Segura-EgeaM Poyato-Ferrera
Jan 16, 2007·Journal of Oral Science·Orlando CatanzaroRicardo R Rodriguez
Apr 22, 2014·Applied and Environmental Microbiology·Katsutaka KuremotoShigeyuki Ebisu
Oct 27, 2018·Brazilian Oral Research·Luciano Tavares Angelo CintraJoão Eduardo Gomes-Filho
Sep 1, 2018·International Endodontic Journal·D Cabanillas-BalseraJ J Segura-Egea
Feb 26, 2016·Brazilian Oral Research·João Eduardo Gomes FilhoEdilson Ervolino
Oct 1, 2006·Journal of Applied Oral Science : Revista FOB·Luci Armada-DiasJosé Freitas Siqueira
Sep 30, 2014·Dental Traumatology : Official Publication of International Association for Dental Traumatology·João Eduardo Gomes-FilhoLuciano Tavares Angelo Cintra
Apr 2, 2015·The Angle Orthodontist·Christopher MurphyFlavio Uribe
Jun 14, 2017·Scientific Reports·Naomichi YonedaMikako Hayashi
Jul 16, 2015·International Endodontic Journal·J J Segura-EgeaL Castellanos-Cosano
Oct 12, 2012·Clinical Oral Investigations·Luciano Tavares Angelo CintraJoão Eduardo Gomes-Filho
Oct 23, 2002·Journal of Clinical Periodontology·M ZehnderG Hasselgren
Apr 25, 2013·Journal of Endodontics·Carlos Frederico B WolleMaria M Campos
Aug 31, 2002·Journal of Clinical Microbiology·Ashraf F FouadJustin D Radolf
Jan 31, 2003·The Journal of the American Dental Association·Ashraf F Fouad, Joseph Burleson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.