Periaqueductal gray-evoked dorsal root reflex is frequency dependent

Brain Research
Yuan Bo PengRichard H Gracely

Abstract

The dorsal root reflex (DRR) is an antidromic action potential originating in the spinal cord that propagates toward the periphery. Given that both GABA(A) and 5-HT(3) receptors are involved in the generation of DRRs and stimulation of the periaqueductal gray (PAG) can induce the release of GABA and serotonin within the spinal cord, we investigated the modulation of DRRs by the PAG descending system. The central end of the cut left L5 dorsal root in adult Sprague-Dawley rats was tested with single fiber recording. Stimulating electrodes were placed in the PAG, sciatic nerve, or transcutaneously across hindpaws. Fifty-seven DRRs were recorded for the effect of PAG stimulation in 19 rats, and 51 DRRs from 26 rats and nine DRRs from seven rats were recorded for an effect of ipsilateral and contralateral peripheral stimulation, respectively. The results were expressed as a percentage of the number of DRRs over the number of stimuli. PAG stimulation at 0.2, 0.5, 5, 20, and 50 Hz produced ratio's of 113.16+/-9.84, 114.54+/-12.22, 24.6+/-3.23, 17.77+/-4.76, and 12.62+/-3.44 (%), respectively. Stimulation at ipsilateral peripheral nerve evoked DRRs of 103.26+/-8.93, 95.27+/-10.57, 37.66+/-7.55, 11.32+/-4.96, and 5.32+/-3.82 (%), respec...Continue Reading

References

May 19, 1989·European Journal of Pharmacology·M HamonD Vergé
Sep 10, 1971·Brain Research·R A LevyE G Anderson
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·G G Holz, E G Anderson
Nov 18, 1993·Neuroreport·K A SlukaK N Westlund
Jan 1, 1952·Cold Spring Harbor Symposia on Quantitative Biology·D P C LLOYD
Dec 1, 1959·The Journal of Physiology·J C ECCLES, K KRNJEVIC
Nov 1, 1961·The Journal of Physiology·J C ECCLESF MAGNI
May 1, 1962·The Journal of Physiology·J C ECCLESW D WILLIS
Oct 1, 1963·The Journal of Physiology·J C ECCLESW D WILLIS
Aug 22, 1935·The Journal of Physiology·D H Barron, B H Matthews
Aug 22, 1935·The Journal of Physiology·D H Barron, B H Matthews
Apr 14, 1938·The Journal of Physiology·D H Barron, B H Matthews
Mar 20, 1949·The Journal of General Physiology·D P C LLOYD, A K McINTYRE

❮ Previous
Next ❯

Citations

Jun 25, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Weirong ZhangPaul W Davenport

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.