Periaqueductal gray neurons exhibit increased responsiveness associated with audiogenic seizures in the genetically epilepsy-prone rat

Neuroscience
P N'Gouemo, C L Faingold

Abstract

The ventrolateral periaqueductal gray is implicated as a component of the neuronal network for audiogenic seizure. This implication is based on immunocytochemical labeling of the proto-oncogene, c-fos, and microinjection studies in the severe substrain of genetically epilepsy-prone rats that exhibits tonic seizures. The present study examines changes in acoustically evoked neuronal responses within the periaqueductal gray in the awake and behaving genetically epilepsy-prone rat as compared to normal Sprague Dawley rats. Two populations of neuronal response were observed in the periaqueductal gray of both genetically epilepsy-prone and normal rats. Most of the neurons exhibited long latencies (>10 ms) and lower thresholds, and were more responsive to the acoustic stimulus. The remainder of the periaqueductal gray neurons exhibited short latencies (<10 ms) and higher thresholds, and exhibited minimal responsiveness to the acoustic stimulus. The mean threshold of periaqueductal gray acoustically evoked neuronal firing of short-latency neurons was significantly higher than normal in the genetically epilepsy-prone rat. The number of acoustically evoked action potentials was significantly elevated in the genetically epilepsy-prone ra...Continue Reading

References

Nov 1, 1992·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·M VaterB Grothe
Apr 1, 1990·Experimental Neurology·C L FaingoldM E Randall
Mar 1, 1986·Electroencephalography and Clinical Neurophysiology·C L FaingoldD M Caspary
Jan 1, 1989·Annals of the New York Academy of Sciences·M Davis
Sep 8, 1986·Life Sciences·J E PennyC M Henley
Aug 1, 1970·Experimental Neurology·J A WadaE Jung
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Jan 1, 1995·Brain Research Bulletin·N B ReeseR D Skinner

❮ Previous
Next ❯

Citations

Oct 22, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Min-Chul ShinChang-Ju Kim
Jan 27, 2004·Physiology & Behavior·Hugo Medeiros Garrido de Paula, Katsumasa Hoshino
May 31, 2001·Brain Research·N OmoriS Chiba
Aug 15, 2000·Neuroscience and Biobehavioral Reviews·K C Ross, J R Coleman
Dec 9, 2003·Behavioural Brain Research·H M G de Paula, Katsumasa Hoshino
Jul 22, 1998·Progress in Neurobiology·C L FaingoldA Riaz
Apr 20, 2000·Epilepsy Research·M F Dutra MoraesN Garcia-Cairasco
Apr 10, 2008·Epilepsia·Lyudmila V Vinogradova, Clementina M van Rijn
Feb 3, 2005·Behavioural Processes·Hugo Medeiros Garrido de PaulaKatsumasa Hoshino
Apr 14, 2016·Epilepsy & Behavior : E&B·Luis J MuñozDolores E López
Aug 1, 2015·Epilepsy & Behavior : E&B·I I PoletaevaI B Fedotova
Jul 6, 2000·Experimental Neurology·J R ColemanK C Ross
Mar 17, 2007·Brain Research·Lyudmila V VinogradovaLeena Tuomisto
Oct 19, 2006·The Journal of Comparative Neurology·Gontzal García Del CañoLuis Martínez-Millán
Mar 2, 2021·Frontiers in Behavioral Neuroscience·Willian Lazarini-LopesNorberto Garcia-Cairasco
Apr 23, 2021·Epilepsy & Behavior : E&B·Willian Lazarini-LopesNorberto Garcia-Cairasco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.