PMID: 6406966Mar 1, 1983Paper

Periaqueductal grey stimulation: an association between selective inhibition of dorsal horn neurones and changes in peripheral circulation

Pain
Arthur W Duggan, C R Morton

Abstract

In barbiturate-anaesthetized and paralysed cats, dorsal horn neurones were studied during electrical stimulation of the periaqueductal grey matter (PAG) and the midbrain ventral tegmentum (VT). Responses to impulses in unmyelinated primary afferents were selectively inhibited by stimulation in the PAG, whereas stimulation in the VT non-selectively reduced both these responses and those to innocuous cutaneous stimuli. Stimulation in the PAG but not the VT produced changes in peripheral circulation. This was observed as a rise in the levels of carbon dioxide in expired air, a rise in muscle temperature in the hind limb and a fall in skin temperature of the pinna or glabrous skin. The combination of suppression of spinal transmission of impulses related to pain and an increase in perfusion of muscles may be a mechanism appropriate to coping with a potentially injurious environment.

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Citations

Oct 22, 1985·European Journal of Pharmacology·F W FoongA W Duggan
Aug 1, 1995·Progress in Neurobiology·M M Behbehani
Oct 21, 2005·Neuroreport·Alexander L GreenTipu Z Aziz
Jul 1, 2010·Neuromodulation : Journal of the International Neuromodulation Society·Alexander L GreenTipu Z Aziz
Apr 11, 2009·Journal of Applied Physiology·Liang-Wu Fu, John C Longhurst
Jan 17, 2009·Brain Research Reviews·M M HeinricherB M Lumb
Oct 11, 2011·Experimental Physiology·Shanika D BasnayakeDavid J Paterson
Nov 4, 2006·The Journal of Physiology·Alexander L GreenDavid J Paterson
Jan 1, 1986·Annals of the New York Academy of Sciences·G W Terman, J C Liebeskind
Jan 1, 1986·Annals of the New York Academy of Sciences·N Zamir, W Maixner
Jun 13, 2012·Nature Reviews. Neurology·Jonathan A HyamAlexander L Green
Jan 1, 1986·Cephalalgia : an International Journal of Headache·O G Berge

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