Peribulbar anaesthesia for cataract surgery: prilocaine versus lignocaine and bupivacaine

Eye
T R Henderson, W Franks

Abstract

Prilocaine has recently been introduced for use in ocular local anaesthesia. A prospective randomised double-masked study was undertaken to assess the efficacy of prilocaine 2% plain versus a mixture of lignocaine 1% and bupivacaine 0.5%, each with hyaluronidase. Seventy-five patients were recruited. Local anaesthetic was given by a two-injection transconjunctival peribulbar technique. Injection and perioperative pain were graded by visual analogue pain score (range 0-10). Akinesia and orbicularis function were graded by the surgeon. The two anaesthetic mixtures were comparable in efficacy in producing anaesthesia and akinesia. Using the Mann-Whitney U-test for significance, pain of injection ranked as a mean of 0.88 for prilocaine and 1.03 for lignocaine and bupivacaine (p = 0.48, U = 635.5) Perioperative pain was ranked as a mean of 1.17 for prilocaine and 0.91 for lignocaine and bupivacaine (p = 0.41, U = 629.0). Prilocaine is a useful alternative anaesthetic agent for eye surgery that has low toxicity and is effective without adrenaline.

References

Dec 1, 1992·Anesthesia and Analgesia·D A SpiegelM M Todd
Mar 1, 1990·Journal of Cataract and Refractive Surgery·J C WhitsettB McClure
Jan 1, 1990·British Journal of Anaesthesia·M GogginJ Blake
Jul 1, 1986·Ophthalmology·J R WittpennA Patz
Aug 1, 1971·American Journal of Ophthalmology·L T Moorman, G S Kenny
Apr 1, 1995·The Journal of General Physiology·M E BräuW Vogel
Dec 1, 1993·The British Journal of Ophthalmology·C Liu, R Redmond
Dec 1, 1993·The British Journal of Ophthalmology·T Ali-MelkkiläH Pälve
Mar 1, 1994·Journal of Cataract and Refractive Surgery·R F HusteadR G Loken

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.