Peribulbar block in patients scheduled for eye procedures and treated with clopidogrel.

Journal of Anesthesia
Emile CalendaMarc Muraine

Abstract

Our hypothesis was that the continuation of clopidogrel does not increase the risk of eye hemorrhage, compared to patients not treated with clopidogrel, when a peribulbar anesthesia is required. Our prospective case-control study enrolled two groups of 1,000 patients scheduled for intraocular eye surgery requiring a peribulbar block. Patients treated with clopidogrel were included in group A (1,000 patients). Patients who had never been treated with clopidogrel constituted the control group (group B, 1,000 patients). Hemorrhages were graded as follows: 1 = spot ecchymosis of eyelid and or subconjunctival hemorrhage; 2 = eyelid ecchymosis involving half the lid surface area; 3 = eyelid ecchymosis all around the eye, no increase in intraocular pressure; 4 = retrobulbar hemorrhage with increased intraocular pressure. Grade 1 hemorrhages were observed in 30 patients (3.0 %) in group A and in 20 patients (2.0 %) in group B. No grade 2, 3, or 4 hemorrhage was encountered. There was no significant difference in the grading of hemorrhage between the groups (p = 0.017). Clopidogrel was not associated with a significant increase in potentially sight-threatening local anesthetic complications.

References

Jul 1, 1995·British Journal of Anaesthesia·R C Hamilton
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Citations

Dec 26, 2015·Journal of Cataract and Refractive Surgery·Irene HuebertArmin Wolf
Jun 7, 2013·Clinical & Experimental Ophthalmology·Adrian T Fung, Alex P Hunyor
Nov 27, 2014·The British Journal of Ophthalmology·K-L Kong, J Khan
Jun 25, 2020·International Ophthalmology Clinics·Sana IdreesAjay E Kuriyan
Jul 20, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Oliver ZeitzThomas Dörner

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