Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study

Circulation
Guido A RositoCaroline S Fox

Abstract

Pericardial fat may be an important mediator of metabolic risk. Correlations with cardiovascular disease risk factors and vascular calcification in a community-based sample are lacking. We sought to examine associations between pericardial fat, metabolic risk factors, and vascular calcification. Participants free of cardiovascular disease from the Framingham Heart Study (n=1155, mean age 63 years, 54.8% women) who were part of a multidetector computed tomography study underwent quantification of intrathoracic fat, pericardial fat, visceral abdominal fat (VAT), coronary artery calcification, and aortic artery calcification. Intrathoracic and pericardial fat volumes were examined in relation to body mass index, waist circumference, VAT, metabolic risk factors, coronary artery calcification, and abdominal aortic calcification. Intrathoracic and pericardial fat were directly correlated with body mass index (r=0.41 to 0.51, P<0.001), waist circumference (r=0.43 to 0.53, P<0.001), and VAT (r=0.62 to 0.76, P<0.001). Both intrathoracic and pericardial fat were associated with higher triglycerides (P<0.0001), lower high-density lipoprotein (P<0.0001), hypertension (P<0.0001 to 0.01), impaired fasting glucose (P<0.0001 to 0.001), diabete...Continue Reading

References

May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthias LöhnArya M Sharma
Feb 13, 2003·Obesity Research·Gianluca IacobellisFrida Leonetti
May 22, 1963·Annals of the New York Academy of Sciences·T R DAWBERL P LYELL
Oct 29, 2003·Circulation·Tomasz MazurekYi Shi
May 27, 2004·Diabetes Care·Alka M KanayaUNKNOWN Health, Aging, and Body Composition (ABC) Study
Jun 16, 2004·Annals of Internal Medicine·Tomoshige HayashiWilfred Y Fujimoto
Jul 21, 2004·Hypertension·Anna Maria SironiEle Ferrannini
Oct 16, 2004·American Journal of Hypertension·Jingzhong DingTamara B Harris
Dec 14, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J-P MontaniA G Dulloo
Jul 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Christine BarandierZhihong Yang
Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·Gianluca Iacobellis, Frida Leonetti
Oct 1, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Elvire HenrichotChristoph A Meier
Aug 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Mikko KankaanpääPatricia Iozzo
Sep 6, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P Maurovich-HorvatU Hoffmann
Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Jin-Won JeongJong Chun Park
May 5, 2007·The American Journal of Cardiology·Howard J WillensEduardo de Marchena
May 12, 2007·The American Journal of Cardiology·Gianluca IacobellisGiuseppe Barbaro

❮ Previous
Next ❯

Citations

May 15, 2010·Herz·Dirk Müller-WielandJörg Kotzka
Sep 20, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y M KimM L Bouxsein
Nov 24, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Yen-Wen WuWei-Shiung Yang
Dec 23, 2011·European Journal of Nuclear Medicine and Molecular Imaging·M Hacker
Apr 16, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Martin GreifAlexander Becker
Nov 3, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jelena Kotur-StevuljevićDanijela Kornic-Ristovski
Mar 16, 2011·Maternal and Child Health Journal·Candace K McClureEleanor Bimla Schwarz
May 5, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matthew JanikPaolo Raggi
Dec 1, 2011·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Teresa TruongAnn Nguyen
Apr 1, 2011·Expert Reviews in Molecular Medicine·Carmine SavoiaRhian M Touyz
Jan 14, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C L SchlettU Hoffmann
Jan 13, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T IrlbeckC S Fox
Jul 7, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B GaboritA Dutour
Nov 30, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y WangW Jia
May 3, 2013·Diabetes Technology & Therapeutics·Kavita GargAnn Scherzinger
Feb 2, 2012·European Heart Journal Cardiovascular Imaging·Tsuyoshi ItoTakahiko Suzuki
Mar 30, 2013·European Heart Journal Cardiovascular Imaging·Daniel DavidovichRosa Sicari
Jun 12, 2013·European Heart Journal Cardiovascular Imaging·Axel Schmermund, Stefan Möhlenkamp
Mar 13, 2012·European Heart Journal·Lokpal S BhatiaChristopher D Byrne
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pedro Iglesias, Juan J Díez
Aug 27, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Gerald V Denis, James A Hamilton
Oct 6, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Amalia GastaldelliRosa Sicari
Sep 14, 2011·Clinical and Experimental Pharmacology & Physiology·Zhi-Yong LiChao-Yu Miao
Jan 12, 2012·International Journal of Endocrinology·Caterina MammiAndrea Fabbri
Jun 8, 2012·International Journal of Endocrinology·M SnelI M Jazet
Jun 19, 2010·Circulation. Arrhythmia and Electrophysiology·George ThanassoulisEmelia J Benjamin
May 28, 2010·Circulation. Arrhythmia and Electrophysiology·Omar BatalMina K Chung
Jul 20, 2010·Circulation. Cardiovascular Imaging·Caroline S FoxJoanne M Murabito
Dec 12, 2012·Circulation Research·Aslan T TurerPhilipp E Scherer
Sep 21, 2011·Hypertension·Meredith C FosterCaroline S Fox
Feb 7, 2014·BMC Cardiovascular Disorders·Fei-Shih YangRicardo C Cury
Jan 24, 2009·Cardiovascular Ultrasound·Thang NguyenDavinder S Jassal
May 7, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Adam J NelsonStephen G Worthley
Nov 16, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Kristofer NymanKirsi Lauerma
Sep 12, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Umjeet S JollyJames A White
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Michael D Jensen
Dec 16, 2011·The Journal of Clinical Endocrinology and Metabolism·Bernhard M KaessCaroline S Fox

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.