Pericardial fluid and serum levels of vascular endothelial growth factor and endostatin in patients with or without coronary artery disease

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Jer-Young LiouPei-Liang Kuan

Abstract

Vascular endothelial growth factor (VEGF) and endostatin are related to ischemic heart disease. This study investigated pericardial fluid and serum levels of VEGF and endostatin in patients with or without ischemic heart disease. A total of 39 patients (24 patients in the CAD group with significant coronary artery disease; 15 patients in the non-CAD group without coronary artery disease) undergoing open heart surgery were enrolled. In the CAD group, patients were classified according to good coronary collateralization (Group A; n = 11) or poor coronary collateralization (Group B; n = 13). Pericardial fluid and serum samples were obtained at the time of surgery. VEGF and endostatin were measured by enzyme-linked immunosorbent assay. The levels of endostatin in both serum and pericardial fluid were significantly lower in the CAD group than in the non-CAD group (130.5 +/- 37.3 ng/mL vs. 172.4 +/- 37.8 ng/mL and 119.0 +/- 25.0 ng/mL vs. 143.0 +/- 23.5 ng/mL). The concentration of serum VEGF in the CAD group (92.6 +/- 18.2 pg/mL) was significantly higher than that in the non-CAD group (75.2 +/- 22.3 pg/mL). The concentration of serum VEGF in Group A (100.1 +/- 20.7 pg/mL) was significantly higher than that in Group B (84.3 +/- 12.4 ...Continue Reading

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Citations

Oct 13, 2010·Pharmacology & Therapeutics·Federica LimanaAntonia Germani
Jun 29, 2007·The Journal of Surgical Research·Hussein M AttaAbdel Moneim F Galal
Dec 5, 2017·Biological & Pharmaceutical Bulletin·Muneyoshi OkadaHideyuki Yamawaki
Oct 5, 2017·Biomarkers in Medicine·Toralph RugeJohan Ärnlöv
Nov 27, 2018·Scandinavian Cardiovascular Journal : SCJ·Toralph RugeJohan Ärnlöv
Jan 20, 2019·Basic Research in Cardiology·Fábio TrindadeInês Falcão-Pires
May 24, 2021·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Ali Fatehi HassanabadPaul Wm Fedak

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