Pericardial infusion of tissue plasminogen activator in fibropurulent pericarditis

Journal of Intensive Care Medicine
Charles P ReznikoffDouglas B Coursin


A 61-year-old man developed a loculated fibropurulent pericarditis, a rare complication of bacteremia. This occurred as a complication of a Staphylococcal aureus bacteremia from a head and neck abscess following self-extraction of a tooth. Despite surgical intervention and placement of 2 pericardial drains, a refractory, inadequately drained infected pericardial effusion persisted. Although there is limited experience with thrombolytic therapy to dissolve a fibrin clot in the pericardium, break down loculated adhesions, and facilitate free drainage of infected material, lysis is well described in the management of exudative pleural effusions. After infusion of 30 mg of tissue plasminogen activator in 100 cc normal saline through the pericardial drain of the patient, a large amount of infected serosanginous material subsequently drained during the next 2 days. The patient became afebrile and culture negative, remained hemodynamically stable, and had resolution of his pericarditis and pericardial effusion on electrocardiogram and echocardiogram, respectively.


Dec 5, 1991·The American Journal of Cardiology·J S Alpert
Feb 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·D D Mann-SegalD Ramasamy
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·D BourosN M Siafakas
May 18, 1999·Archives of Disease in Childhood·R JunejaA Joshi
Jun 30, 2001·Intensive Care Medicine·P G Bridgman
Mar 1, 1951·The Journal of the International College of Surgeons·L T WRIGHTE T QUASH

❮ Previous
Next ❯


May 15, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael T BighamHector R Wong
May 18, 2011·Critical Care : the Official Journal of the Critical Care Forum·Pascal AugustinPhilippe Montravers
Oct 21, 2015·Critical Reviews in Microbiology·Marijke PeetermansPeter Verhamme
Jul 21, 2012·Journal of Pediatric Surgery·Anna C ShawyerJacob C Langer
Jan 27, 2007·Pharmacotherapy·Kelly K JohnsonParag Patel

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Michael T BighamHector R Wong
© 2022 Meta ULC. All rights reserved