Pericardiectomy vs medical management in patients with relapsing pericarditis

Mayo Clinic Proceedings
Masud H KhandakerJae K Oh


To determine whether surgical pericardiectomy is a safe and effective alternative to medical management for chronic relapsing pericarditis. Retrospective review of 184 patients presenting to the Mayo Clinic in Rochester, Minnesota, from January 1, 1994, through December 31, 2005, with persistent relapsing pericarditis identified 58 patients who had a pericardiectomy after failed medical management and 126 patients who continued with medical treatment only. The primary outcome variables were in-hospital postoperative mortality or major morbidity, all-cause death, time to relapse, and medication use. Mean ± SD follow-up was 5.5 ± 3.5 years in the surgical group and 5.4 ± 4.4 years in the medical treatment group. At baseline, patients in the surgical group had higher mean relapses (6.9 vs 5.5; P=.01), were more likely to be taking colchicine (43.1% [n=25] vs 18.3% [n=23]; P=.002) and corticosteroids (70.7% [n=41] vs 42.1% [n=53]; P<.001), and were more likely to have undergone a prior pericardiotomy (27.6% [n=16] vs 11.1% [n=14]; P=.003) than the medical treatment group. Perioperative mortality (0%) and major morbidity (3%; n=2) were minimal. Kaplan-Meier analysis revealed no differences in all-cause death at follow-up (P=.26); ho...Continue Reading


Jun 26, 2003·The Annals of Thoracic Surgery·A Laurie W ShroyerUNKNOWN Society of Thoracic Surgeons
May 4, 2004·European Heart Journal·Bernhard MaischUNKNOWN Task Force on the Diagnosis and Management of Pricardial Diseases of the European Society of Cardiology
Oct 16, 2004·Heart·Jordi Soler-SolerGaietà Permanyer-Miralda
Nov 19, 2004·The New England Journal of Medicine·Richard A Lange, L David Hillis
Aug 30, 2005·The American Journal of Cardiology·Massimo ImazioRita Trinchero
Sep 11, 2007·The American Journal of Cardiology·Massimo ImazioRita Trinchero
Jun 1, 2010·Mayo Clinic Proceedings·Masud H KhandakerJae K Oh

❮ Previous
Next ❯


Apr 30, 2014·Revista Española De Cardiología·Massimo Imazio
Dec 23, 2015·Expert Review of Cardiovascular Therapy·Syed Wamique YusufPatrick T O'Gara
Apr 10, 2015·Heart·Massimo Imazio, Fiorenzo Gaita
Aug 12, 2015·Nature Reviews. Cardiology·Massimo ImazioFiorenzo Gaita
Mar 24, 2016·Current Cardiology Reports·Alexander FardmanYehuda Adler
Jan 26, 2016·Journal of Cardiovascular Medicine·Massimo ImazioYehuda Adler
Apr 25, 2016·Current Cardiology Reports·Massimo ImazioPhilippe Charron
May 24, 2016·The Journal of Thoracic and Cardiovascular Surgery·Erin A GillaspieJoseph A Dearani
Oct 12, 2016·Progress in Cardiovascular Diseases·Massimo ImazioFiorenzo Gaita
Nov 9, 2016·The Annals of Thoracic Surgery·Erin A GillaspieJohn M Stulak
Jun 25, 2015·Revista da Associação Médica Brasileira·Márcio ToniniFábio Fernandes
Aug 15, 2018·Expert Review of Cardiovascular Therapy·Alessandro Galluzzo, Massimo Imazio
Apr 24, 2013·Circulation·Leonard S Lilly
Feb 13, 2019·Current Cardiology Reports·Shinya Unai, Douglas R Johnston
Jul 25, 2019·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Husam H BalkhyDiego Avella-Patino
Nov 12, 2019·Expert Review of Cardiovascular Therapy·Alessandro AndreisGaetano Maria de Ferrari
May 22, 2017·Current Cardiology Reports·Bo XuPaul C Cremer
Jan 26, 2017·Nursing·Roberta Kaplow, Karen Iyere
Nov 5, 2019·Frontiers in Pediatrics·Enrico TombettiRolando Cimaz
Jan 17, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Tevfik F Ismail
Aug 20, 2019·Expert Review of Cardiovascular Therapy·Michael ChetritMilind Y Desai
Jan 11, 2020·Journal of the American College of Cardiology·Juan Guido ChiabrandoAntonio Abbate
Feb 9, 2021·European Heart Journal. Case Reports·Simran ShergillNaomi Cairns
Feb 21, 2021·Autoimmunity Reviews·Albrecht BetrainsSteven Vanderschueren
Mar 1, 2021·Internal and Emergency Medicine·Alessandro AndreisAntonio Brucato
Apr 9, 2019·Autoimmunity Reviews·Nathan Peiffer-SmadjaPatrice Cacoub

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.