PMID: 11596053Oct 12, 2001Paper

Pericellular Griffonia simplicifolia I isolectin B4-binding ring structures in the dorsal root ganglia following peripheral nerve injury in rats

The Journal of Comparative Neurology
L Li, X F Zhou


Patients with a peripheral nerve injury often suffer from persistent chronic pain, but the underlying mechanism remains largely unknown. The persistent nature of the pain suggests injury-induced profound structural changes along the sensory pathways. In the present study, using the plant Griffonia simplicifolia I isolectin B4 (IB4) as a marker for nonpeptidergic small sensory neurons, we sought to examine whether these neurons sprout in the dorsal root ganglia (DRG) in response to peripheral nerve injury. The lumbar 5 (L5) spinal nerve was transected, and rats were allowed to survive for varying lengths of time before IB4 histology was performed. We found that a subpopulation of IB4-positive sensory neurons sprouted robustly after spinal nerve injury. Twelve weeks after spinal nerve injury, the IB4-positive ring structures became dramatic and encircled both large and small neurons in the DRG. The aberrant sprouting of small sensory neurons was also demonstrated by retrograde labeling. The processes of satellite cells surrounding large sensory neurons also became IB4 positive, and 87.8% of perineuronal IB4-positive ring structures intermingled and/or coexpressed with glial fibrillary acidic protein-positive satellite cells. Thus...Continue Reading


Jan 1, 1987·Annual Review of Physiology·P A D'Amore, R W Thompson
Nov 1, 1989·The Journal of Clinical Investigation·D T ConnollyJ Feder
Jan 1, 1994·Trends in Neurosciences·T HökfeltZ Wiesenfeld-Hallin
Jan 5, 1995·Biochimica Et Biophysica Acta·K P ClaffeyB M Spiegelman
Oct 1, 1994·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·B CalzadaJ A Vega
May 1, 1993·Journal of Neurocytology·X Lu, P M Richardson
Dec 1, 1995·The European Journal of Neuroscience·R R JiT Hökfelt
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BussolinoG Persico
Jun 1, 1997·The European Journal of Neuroscience·J B Munson, S B McMahon
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·P MärzS Rose-John
Aug 1, 1998·Circulation Research·Z Zukowska-GrojecD S Grant

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