PMID: 11596053Oct 12, 2001Paper

Pericellular Griffonia simplicifolia I isolectin B4-binding ring structures in the dorsal root ganglia following peripheral nerve injury in rats

The Journal of Comparative Neurology
L Li, X F Zhou

Abstract

Patients with a peripheral nerve injury often suffer from persistent chronic pain, but the underlying mechanism remains largely unknown. The persistent nature of the pain suggests injury-induced profound structural changes along the sensory pathways. In the present study, using the plant Griffonia simplicifolia I isolectin B4 (IB4) as a marker for nonpeptidergic small sensory neurons, we sought to examine whether these neurons sprout in the dorsal root ganglia (DRG) in response to peripheral nerve injury. The lumbar 5 (L5) spinal nerve was transected, and rats were allowed to survive for varying lengths of time before IB4 histology was performed. We found that a subpopulation of IB4-positive sensory neurons sprouted robustly after spinal nerve injury. Twelve weeks after spinal nerve injury, the IB4-positive ring structures became dramatic and encircled both large and small neurons in the DRG. The aberrant sprouting of small sensory neurons was also demonstrated by retrograde labeling. The processes of satellite cells surrounding large sensory neurons also became IB4 positive, and 87.8% of perineuronal IB4-positive ring structures intermingled and/or coexpressed with glial fibrillary acidic protein-positive satellite cells. Thus...Continue Reading

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Citations

Apr 12, 2008·Purinergic Signalling·Zoltan Gerevich, Peter Illes
Jul 8, 2008·Experimental Neurology·N D T Zinck, J W Downie
Nov 8, 2007·Genesis : the Journal of Genetics and Development·Mino D BelleRichard Morris
Nov 21, 2007·The Journal of Comparative Neurology·Tom ChaoRanjan Gupta
May 4, 2002·Nature Reviews. Neuroscience·Matti S Airaksinen, Mart Saarma
Apr 7, 2009·European Journal of Pain : EJP·Tian-Ying HuangMenachem Hanani
Mar 15, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dan-dan SongYao-zong Yuan
Apr 10, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·April N HerrityCharles H Hubscher
Mar 7, 2020·Journal of Oral Science·Masamichi ShinodaKoichi Iwata
May 9, 2019·Journal of Dental Anesthesia and Pain Medicine·Koichi Iwata, Masamichi Shinoda
Sep 27, 2019·Toxicologic Pathology·LaTasha K Crawford, Michael J Caterina
Dec 29, 2020·Frontiers in Cellular Neuroscience·Emily L Tran, LaTasha K Crawford

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