Periconceptional dietary intake of choline and betaine and neural tube defects in offspring

American Journal of Epidemiology
Gary M ShawDonna M Schaffer

Abstract

Periconceptional intake of folic acid prevents some neural tube defects (NTDs). Other nutrients may also contribute to NTD etiologies; a likely candidate is choline. Similar to folic acid, choline is involved in one-carbon metabolism for methylation of homocysteine to methionine. The authors investigated whether maternal periconceptional dietary intakes of choline and its metabolite betaine influence NTD risk. Data were derived from a case-control study of fetuses and infants with NTDs among 1989-1991 California births. In-person interviews were conducted with mothers of 424 NTD cases and with mothers of 440 nonmalformed controls. A standard 100-item food frequency questionnaire was used to assess nutrient intake. Dietary intakes of choline were associated with reduced NTD risks. Controlling for intake of supplemental folic acid, dietary folate, dietary methionine, and other covariates did not substantially influence risk estimates for choline. NTD risk estimates were lowest for women whose diets were rich in choline, betaine, and methionine. That is, for women whose intake was above the 75th percentile compared with below the 25th percentile for all three nutrients, the odds ratio was 0.17 (95% confidence interval: 0.04, 0.76)...Continue Reading

References

Dec 24, 1992·The New England Journal of Medicine·A E Czeizel, I Dudás
Jan 1, 1990·Journal of Clinical Epidemiology·G BlockC Clifford
Jan 1, 1987·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·W G McBride, L J Hicks
Sep 1, 1986·American Journal of Epidemiology·G BlockL Gardner
Jan 16, 1995·American Journal of Medical Genetics·J K FrielF C Fraser
Dec 1, 1994·Metabolism: Clinical and Experimental·R P Steegers-TheunissenT K Eskes
Feb 1, 1994·American Journal of Obstetrics and Gynecology·D K WallerG G Rhoads
Apr 10, 1996·JAMA : the Journal of the American Medical Association·M M WerlerA A Mitchell
Apr 10, 1996·JAMA : the Journal of the American Medical Association·G M ShawD Schaffer
Jun 1, 1997·Journal of the American Dietetic Association·E P Shronts
Jan 1, 1997·Nutrition and Cancer·M L SlatteryJ D Potter
Sep 18, 1999·American Journal of Epidemiology·E M VelieM Kulldorff
Oct 7, 2000·Journal of the American College of Nutrition·S H Zeisel
Jun 11, 2002·Annual Review of Nutrition·Ignatia B Van den Veyver
Feb 1, 2003·Annals of Epidemiology·Lucina SuarezElaine Gunter
Mar 4, 2003·The Journal of Nutrition·Joel B Mason
May 6, 2003·The Journal of Nutrition·Steven H ZeiselJoanne M Holden

❮ Previous
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Citations

May 7, 2010·Journal of Inherited Metabolic Disease·Per Magne Ueland
Sep 22, 2011·Neuroscience Bulletin·Elisabetta Biasi
Nov 30, 2011·The Proceedings of the Nutrition Society·Paula Dominguez-SalasSophie E Moore
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mihai G MehedintSteven H Zeisel
Nov 6, 2009·The Journal of Biological Chemistry·Kerry-Ann da CostaSteven H Zeisel
Nov 10, 2010·The Journal of Biological Chemistry·Mary E ResseguieSteven H Zeisel
Aug 12, 2008·Journal of the American College of Nutrition·Jean HungMarie A Caudill
Aug 10, 2007·Journal of the National Cancer Institute·Eunyoung ChoEdward L Giovannucci
Aug 10, 2007·Journal of the National Cancer Institute·Regina G Ziegler, Unhee Lim
Jul 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kerry-Ann da CostaSteven H Zeisel
Jan 31, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xinran XuJia Chen
Apr 26, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mary ResseguieSteven H Zeisel
Dec 3, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vesela P KovachevaJan Krzysztof Blusztajn
Sep 16, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mihai G MehedintSteven H Zeisel
Apr 8, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ShaSteven H Zeisel
Aug 22, 2008·Nutrition Today·Lisa M Sanders, Steven H Zeisel
Jul 20, 2006·Annual Review of Nutrition·Steven H Zeisel
Aug 24, 2011·Journal of Nutrigenetics and Nutrigenomics·Greg C SmithLynnette R Ferguson
Mar 9, 2010·Journal of the International Society of Sports Nutrition·Shona S CraigSteven H Zeisel
Apr 5, 2012·Journal of the International Society of Sports Nutrition·J Luke PryorThomas Swensen
May 6, 2006·Nutrition Reviews·Steven H Zeisel, Mihai D Niculescu
Sep 21, 2013·International Journal of Environmental Research and Public Health·Apolline ImbardHenk J Blom
Dec 3, 2011·The American Journal of Clinical Nutrition·Anna E BeaudinPatrick J Stover
Jan 1, 2009·The American Journal of Clinical Nutrition·Steven H Zeisel
Jan 1, 2009·The American Journal of Clinical Nutrition·Steven H Zeisel
Jun 11, 2010·The American Journal of Clinical Nutrition·Leslie M FischerSteven H Zeisel
Jan 29, 2011·The Journal of Nutrition·Steven H Zeisel
Jul 12, 2008·Nutritional Neuroscience·Francisco J Rosales, Steven H Zeisel
Apr 1, 2014·Trends in Endocrinology and Metabolism : TEM·Xinyin JiangMarie A Caudill
Oct 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Martin KohlmeierSteven H Zeisel
Jan 11, 2014·The Proceedings of the Nutrition Society·Donald J McNamara
Dec 1, 2010·Nutrition Reviews·W Philip T James

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