Periconceptional Folic Acid Supplementation Benefit to Development of Early Sensory-Motor Function through Increase DNA Methylation in Rat Offspring

Nutrients
Wen LiGuowei Huang

Abstract

Periconceptional maternal folate levels may alter DNA methylation patterns and health outcomes in offspring. We hypothesized that maternal folic acid supplementation alters fetal neural development through DNA methylation in the fetal brain. Twenty-eight rats were randomly assigned to four groups: three groups of the female rats were fed folate-normal, folate-deficient or folate-supplemented diets from seven days before mating to delivery. In another group, folic acid supplementation diet short-period group was fed a folate-normal diet, except for 10 days (begin mating) when this group was fed a folate-supplemented diet. After delivery, the diets were changed to folate-normal diet for all four groups. The cliff avoidance and forelimb grip tests were used to assess sensory motor function of rat offspring. The results indicate that maternal folic acid supplementation improved the early development of sensory-motor function in offspring. Maternal folic acid supplementation increased the methylation potential, global DNA methylation (5-mC) and DNA methyltransferase expression and activity in the brains of the offspring. In conclusion, maternal folic acid supplementation increases DNA methylation pattern in offspring brain and impro...Continue Reading

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Citations

Nov 18, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Wen LiGuowei Huang
Oct 13, 2018·International Journal of Molecular Sciences·Kuniyasu Soda
Mar 4, 2020·Reproductive Sciences·Huan-Yu LiuYuan-Zhen Zhang
Jan 28, 2019·Science China. Life Sciences·Kexin ZouHefeng Huang
Jan 16, 2021·Cells·Ganchimeg DavaaJung Keun Hyun
Nov 1, 2020·International Journal of Molecular Sciences·Grégory PouriéCarine Bossenmeyer-Pourié
Apr 1, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lara CaneverAlexandra I Zugno
Dec 7, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Runyu ZouTonya White
Feb 27, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Omyma G AhmedNessren M Abd El-Rady

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

SAS
SPSS

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