Pericytes as targets in hereditary hemorrhagic telangiectasia

Frontiers in Genetics
Jérémy ThalgottFranck Lebrin

Abstract

Defective paracrine Transforming Growth Factor-β (TGF-β) signaling between endothelial cells and the neighboring mural cells have been thought to lead to the development of vascular lesions that are characteristic of Hereditary Hemorrhagic Telangiectasia (HHT). This review highlights recent progress in our understanding of TGF-β signaling in mural cell recruitment and vessel stabilization and how perturbed TGF-β signaling might contribute to defective endothelial-mural cell interaction affecting vessel functionalities. Our recent findings have provided exciting insights into the role of thalidomide, a drug that reduces both the frequency and the duration of epistaxis in individuals with HHT by targeting mural cells. These advances provide opportunities for the development of new therapies for vascular malformations.

References

Jan 1, 1986·Tissue & Cell·D E Sims
Dec 1, 1988·Journal of Clinical Gastroenterology·E Van CutsemG Vantrappen
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoJ Folkman
Jun 23, 1994·The New England Journal of Medicine·H I SabaL A Logrono
Sep 5, 1996·Nature·P CarmelietD Collen
Jan 15, 1999·Acta Physiologica Scandinavica·G K Owens
May 29, 1999·Science·D Y LiD P Wendel
Nov 24, 1999·The Journal of Clinical Investigation·A BourdeauM Letarte
Nov 24, 1999·The New England Journal of Medicine·S SinghalB Barlogie
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P OhE Li
May 10, 2001·Trends in Cardiovascular Medicine·A BourdeauM Letarte
Apr 3, 2002·The EMBO Journal·Marie-José GoumansPeter ten Dijke
Feb 18, 2003·Human Molecular Genetics·Sudha SrinivasanDouglas A Marchuk
Jun 18, 2003·The Journal of Cell Biology·Holger GerhardtChrister Betsholtz
Jul 29, 2003·Cell and Tissue Research·Holger Gerhardt, Christer Betsholtz
Feb 10, 1962·Lancet·A L SPEIRS
Sep 23, 2003·Genesis : the Journal of Genetics and Development·Lieve UmansAn Zwijsen
Jan 30, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bin XuGuo-Yuan Yang
Aug 3, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hideyuki BeppuKenneth D Bloch
Sep 24, 2004·The EMBO Journal·Franck LebrinPeter ten Dijke
May 10, 2005·Journal of Medical Genetics·S A Abdalla, M Letarte
Jul 5, 2005·Journal of Medical Genetics·S G ColeC L Shovlin
Aug 18, 2005·Journal of Cell Science·Aristidis Moustakas, Carl-Henrik Heldin
Aug 27, 2005·The Journal of Pharmacology and Experimental Therapeutics·Ulrike SeayOliver Eickelberg

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Citations

Aug 30, 2017·Respiration; International Review of Thoracic Diseases·Sophie Dupuis-GirodC L Shovlin
Aug 11, 2017·Expert Opinion on Therapeutic Targets·Lidia Ruiz-LlorenteCarmelo Bernabeu
May 31, 2018·Cell Transplantation·Jyoti Gautam, Yao Yao
Jan 6, 2018·Journal of Neurosurgery·Ethan A WinklerMichael T Lawton
Jul 15, 2015·Seminars in Immunopathology·Yoshihide Asano, Shinichi Sato
Mar 16, 2017·International Forum of Allergy & Rhinology·Thomas ParzefallDominik Riss
Nov 15, 2018·Frontiers in Cardiovascular Medicine·Mark Sweeney, Gabor Foldes
Oct 14, 2020·Clinical and Translational Science·Mayur SarangdharBruce R Yacyshyn
Mar 7, 2021·International Journal of Molecular Sciences·Wineke BakkerMarie José T H Goumans

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