Pericytes, microvasular dysfunction, and chronic rejection

Transplantation
Malgorzata KlocRafik M Ghobrial

Abstract

Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Thus, there is a persistent quest for development of antichronic rejection therapies and identification of novel molecular and cellular targets. One of the potential targets is the pericytes, the mural cells of microvessels, which regulate microvascular permeability, development, and maturation by controlling endothelial cell functions and regulating tissue fibrosis and inflammatory response. In this review, we discuss the potential of targeting pericytes in the development of microvasular dysfunction and the molecular pathways involved in regulation of pericyte activities for antichronic rejection intervention.

References

Apr 1, 1991·The Journal of Cell Biology·V Nehls, D Drenckhahn
Mar 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O SkalliL Orci
Jan 1, 1986·Tissue & Cell·D E Sims
May 1, 1985·The Journal of Cell Biology·N C JoyceG E Palade
Aug 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D Shepro, N M Morel
Mar 15, 2000·Brain Research Bulletin·H K RuckerW E Thomas
Sep 22, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·S Loughna, T N Sato
Dec 26, 2001·Microvascular Research·Ugur OzerdemWilliam B Stallcup
Aug 17, 2002·The Journal of Biological Chemistry·Valerie PerrotJ Silvio Gutkind
May 6, 2003·Circulation Research·Georgina CollettAnn E Canfield
Jun 5, 2003·Nature Medicine·Peter Carmeliet
Jul 29, 2003·Cell and Tissue Research·Holger Gerhardt, Christer Betsholtz
Sep 30, 2003·Thrombosis and Haemostasis·Rashmi YadavSussan Nourshargh
Oct 9, 2003·American Journal of Physiology. Cell Physiology·Alexey Y KolyadaIra M Herman
May 12, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heyman LuckrazJohn Wallwork
Jul 28, 2004·Investigative Ophthalmology & Visual Science·Suzanne Hughes, Tailoi Chan-Ling
Sep 17, 2004·Transplantation·Binnaz Handan OzdemirMehmet Haberal
Oct 7, 2004·Circulation·C Farrington-RockA E Canfield
Dec 21, 2004·Angiogenesis·Ugur Ozerdem, William B Stallcup
Apr 6, 2005·Journal of Molecular and Cellular Cardiology·Takashi OmuraJunichi Yoshikawa
Apr 13, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Walter L MurfeeShayn M Peirce
May 19, 2005·Molecular and Cellular Biology·Kazunobu TachibanaAlan Bernstein
Sep 17, 2005·Circulation Research·Annika ArmulikChrister Betsholtz
Oct 11, 2005·Neuro-oncology·Gabriele Bergers, Steven Song
Nov 24, 2005·Investigative Ophthalmology & Visual Science·Yong LiMichele C Madigan
Dec 1, 2005·The Journal of Biological Chemistry·Shiyou ChenRobert J Lechleider

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Citations

Dec 5, 2015·Frontiers in Immunology·Paulina RuizMaria Rosa Bono
Aug 25, 2016·The American Journal of Pathology·Luke BarronJeremy S Duffield
Sep 22, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·El Bairi KhalidAgnieszka Najda
Nov 26, 2016·Regenerative Medicine·Giuseppe MangialardiPaolo Madeddu
Apr 9, 2020·Cell Communication and Signaling : CCS·Roghayyeh BaghbanPeyman Zare
Jan 23, 2019·Brain : a Journal of Neurology·Luc BertrandMichal Toborek

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