Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell line

Neoplasma
X LinX Li

Abstract

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is the major clinical impediment to chemotherapy of breast cancers. Down-regulation of PI3K/Akt pathway has been described as related to reversal of MDR in cancer cells. Here, we investigated the reversal effect on MDR phenotype of perifosine, a new Akt inhibitor, in breast cancer cell lines. In this study, MCF-7/ADM cells and MCF-7 cells were treated with different concentrations of perifosine. Our results suggested that perifosine reversed MDR partially by downregulation of P-gp expression and inhibition of PI3K/Akt/NF-κB pathway in the MCF-7/ADM cell line. The novel Akt inhibitor perifosine may be a promising new drug due to its ability to reverse MDR in human breast cancer cells.

Citations

Mar 29, 2014·International Journal of Molecular Medicine·Min LiuYong-Ning Zhou
Dec 1, 2017·International Journal of Molecular Sciences·Marilina García-Aranda, Maximino Redondo
Aug 20, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yiping DuTongshan Wang
Jul 1, 2016·Molecular Medicine Reports·Mingxia ZhuTongshan Wang
Dec 6, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yihao ZhangDujuan Xu
Jun 9, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Amir Sadra Zangouei, Meysam Moghbeli
Apr 8, 2020·ACS Pharmacology & Translational Science·Marion Le GrandMaria Kavallaris

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