Perifosine sensitizes UVB-induced apoptosis in skin cells: new implication of skin cancer prevention?

Cellular Signalling
Chao JiZhigang Bi

Abstract

We demonstrate here that a relative low dose of perifosine significantly enhanced UVB-induced apoptosis in skin cells (keratinocytes and fibroblasts), associated with a significant increase of reactive oxygen species (ROS) and ceramide production as well as multiple perturbations of diverse cell signaling pathways, shifting to a significant pro-apoptosis outcomes. Perifosine inhibited UVB-induced pro-survival Akt/mammalian target of rapamycin (mTOR) and ERK activation, while facilitating pro-apoptotic AMP-activated protein kinas (AMPK), c-Jun-NH(2)-kinase (JNK), and p53 activation; these signaling changes together promoted a striking increase in skin cell apoptosis and a significantly reduced amount of DNA damages. Our results suggest that perifosine may represent a novel skin cancer prevention strategy.

References

Mar 20, 1996·Journal of the National Cancer Institute·M R GailaniA E Bale
Mar 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P HilgardJ Engel
Oct 13, 1999·Mutation Research·A Sarasin
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·G A RuiterW J van Blitterswijk
Jun 8, 2001·Cancer Chemotherapy and Pharmacology·A G CharlesM C Cabot
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·F R de GruijlL H Mullenders
Jan 26, 2002·The International Journal of Biochemistry & Cell Biology·Kamal DattaParthaprasad Chattopadhyay
Mar 19, 2002·Frontiers in Bioscience : a Journal and Virtual Library·James E Cleaver, Eileen Crowley
Sep 20, 2002·Skin Pharmacology and Applied Skin Physiology·Frank R de Gruijl
Oct 2, 2002·Current Oncology Reports·Rajendra G Mehta, John M Pezzuto
Apr 8, 2004·Current Opinion in Urology·Eric A Klein, Ian M Thompson
Jun 1, 2005·Biochimica Et Biophysica Acta·Leena Latonen, Marikki Laiho
Jul 14, 2005·Investigational New Drugs·Stefan R VinkMarcel Verheij
Mar 1, 2006·Molecular Cancer Therapeutics·Shannon Reagan-ShawNihal Ahmad
Aug 18, 2006·Nature Reviews. Cancer·David M Sabatini
Jul 7, 2007·Cancer Cell·David A Guertin, David M Sabatini
Dec 7, 2007·The Journal of Biological Chemistry·Rintaro OkoshiHarutoshi Kizaki
Aug 22, 2008·The Journal of Biological Chemistry·Cong CaoYinsheng Wan
Feb 17, 2009·Current Oncology Reports·Joell J Gills, Phillip A Dennis
Apr 11, 2009·Journal of Cellular Physiology·Cong Cao, Yinsheng Wan
Mar 7, 2012·Clinical Science·Shaobin WangMing-Hui Zou

❮ Previous
Next ❯

Citations

Aug 16, 2012·Biochemical and Biophysical Research Communications·Chao JiZhi-Gang Bi
Sep 1, 2012·Biochemical and Biophysical Research Communications·Ting GongGuo-zhen Sun
Dec 22, 2015·Biochemical and Biophysical Research Communications·Koulong ZhengBiao Xu
Aug 1, 2014·The Journal of Investigative Dermatology·Yi-Ming ZhangCong Cao
Mar 13, 2016·Biochemical and Biophysical Research Communications·Ying ZouXuemin Wang
Nov 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen-Li HsuTohru Yoshioka
Aug 14, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie ShenJian-Li Zhang
Feb 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianli ZhangJie Shen
Nov 10, 2012·Biochimica Et Biophysica Acta·Wim J van Blitterswijk, Marcel Verheij
Feb 13, 2018·Journal of Experimental & Clinical Cancer Research : CR·Jiang JiangZeyao Tang
Nov 17, 2016·Biochemical and Biophysical Research Communications·Jifeng NieLin Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.