Perihematoma cerebral blood flow is unaffected by statin use in acute intracerebral hemorrhage patients

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Laura C GioiaICH ADAPT investigators

Abstract

Statin therapy has been associated with improved cerebral blood flow (CBF) and decreased perihematoma edema in animal models of intracerebral hemorrhage (ICH). We aimed to assess the relationship between statin use and cerebral hemodynamics in ICH patients. A post hoc analysis of 73 ICH patients enrolled in the Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial (ICH ADAPT). Patients presenting <24 hours from ICH onset were randomized to a systolic blood pressure target <150 or <180 mm Hg with computed tomography perfusion imaging 2 hours after randomization. Cerebral blood flow maps were calculated. Hematoma and edema volumes were measured planimetrically. Regression models were used to assess the relationship between statin use, perihematoma edema and cerebral hemodynamics. Fourteen patients (19%) were taking statins at the time of ICH. Statin-treated patients had similar median (IQR Q25 to 75) hematoma volumes (21.1 (9.5 to 38.3) mL versus 14.5 (5.6 to 27.7) mL, P=0.25), but larger median (IQR Q25 to 75) perihematoma edema volumes (2.9 (1.7 to 9.0) mL versus 2.2 (0.8 to 3.5) mL, P=0.02) compared with nontreated patients. Perihematoma and ipsilateral hemispheric CBF were similar in both groups. A multivariate ...Continue Reading

References

Nov 1, 1989·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·R A RobbM C Stacy
Jun 1, 1981·Journal of Computer Assisted Tomography·R A ClasenJ J Lobick
Oct 19, 1996·Lancet·C J VaughanB M Buckley
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M EndresJ K Liao
Apr 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M YamadaM A Moskowitz
Nov 2, 2002·Stroke; a Journal of Cerebral Circulation·James M GebelJoseph P Broderick
Nov 2, 2002·Stroke; a Journal of Cerebral Circulation·James M GebelJoseph P Broderick
Feb 20, 2003·European Heart Journal·P O BonettiA Lerman
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ona WuA Gregory Sorensen
Jan 22, 2005·Fundamental & Clinical Pharmacology·Michael Schachter
Apr 13, 2005·Brain Research·Alireza P ShabanzadehChen Xu Wang
Dec 20, 2005·Lancet Neurology·Guohua XiJulian T Hoff
Aug 11, 2006·The New England Journal of Medicine·Pierre AmarencoUNKNOWN Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators
Mar 16, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Colin P DerdeynWilliam J Powers
Aug 19, 2007·Neurocritical Care·Neeraj S NavalJuan R Carhuapoma
Dec 10, 2009·Neurology·H ArimaUNKNOWN INTERACT Investigators
Jun 12, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·Kenneth ButcherAndrew M Demchuk
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Chitra VenkatasubramanianChristine Anne Wijman
Apr 2, 2011·Stroke; a Journal of Cerebral Circulation·Andria L FordJin-Moo Lee
Mar 24, 2012·Stroke; a Journal of Cerebral Circulation·Dar DowlatshahiUNKNOWN Registry of the Canadian Stroke Network
Aug 30, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sotirios GiannopoulosRandolph S Marshall
Jan 16, 2013·Circulation·Francesco VioliPasquale Pignatelli
Feb 9, 2013·Stroke; a Journal of Cerebral Circulation·Kenneth S ButcherUNKNOWN ICH ADAPT Investigators
Mar 6, 2013·Journal of Behavioral and Brain Science·Dongmei YangDonald M Seyfried
May 30, 2013·The New England Journal of Medicine·Craig S AndersonUNKNOWN INTERACT2 Investigators
Apr 3, 2014·Stroke; a Journal of Cerebral Circulation·Rebecca McCourtUNKNOWN ICH ADAPT Investigators

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT00963976

Software Mentioned

PerfScape
Analyze
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Stroke; a Journal of Cerebral Circulation
Kenneth ButcherICH ADAPT investigators
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Mahesh KateICHADAPT Investigators
© 2022 Meta ULC. All rights reserved