Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes.

Neurosurgery
Wajd N Al-HolouRaymond Sawaya

Abstract

Resection is a critical component in the initial treatment of glioblastoma (GBM). Often GBMs are resected using an intralesional method. Circumferential perilesional resection of GBMs has been described, but with limited data. To conduct an observational retrospective analysis to test whether perilesional resection produced a greater extent of resection. We identified all patients with newly diagnosed GBM who underwent resection at our institution from June 1, 1993 to December 31, 2015. Demographics, presenting symptoms, intraoperative data, method of resection (perilesional or intralesional), volumetric imaging data, and postoperative outcomes were obtained. Complete resection (CR) was defined as 100% resection of all contrast-enhancing disease. Univariate analyses employed analysis of variance (ANOVA) and Fisher's exact test. Multivariate analyses used propensity score-weighted multivariate logistic regression. Newly diagnosed GBMs were resected in 1204 patients, 436 tumors (36%) perilesionally and 766 (64%) intralesionally. Radiographic CR was achieved in 69% of cases. Multivariate analysis demonstrated that perilesional tumor resection was associated with a significantly higher rate of CR than intralesional resection (81% v...Continue Reading

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Citations

Feb 22, 2021·World Neurosurgery·Ian E McCutcheon, Mark C Preul
Mar 21, 2021·Journal of Cancer Research and Clinical Oncology·Ljupcho EfremovDaniel Medenwald
Apr 6, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philipp KarschniaJoerg-Christian Tonn
Jan 8, 2022·Journal of Neurosurgery·Wajd N Al-HolouFrederick F Lang

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