Perimenstrual migraines and their response to preventive therapy with topiramate

Cephalalgia : an International Journal of Headache
Gianni AllaisJoop van Oene

Abstract

Preventive treatment with topiramate is effective for overall reduction of migraine frequency, but there are few data regarding its efficacy on perimenstrual migraines. To determine whether topiramate can prevent perimenstrual migraines, we analyzed data from premenopausal women as a subgroup of the Prolonged Migraine Prevention with Topiramate (PROMPT) study. In total, 198 women from the PROMPT study with menstrually related migraine (MRM) were evaluated. After a one-to-two-month prospective baseline period, patients received open-label topiramate (50-200 mg/day) for six months. During topiramate treatment, mean monthly migraine frequency was reduced from 7.03 at baseline to 4.36 (mean change: -2.66; p < .001, endpoint analysis). Mean percentage reductions were similar for migraines during and outside the perimenstrual period (-45.9% and -46.1%, respectively). In patients with aura, reductions in migraine days with (-48.3%) or without (-43.4%) aura were similar to those in patients without aura (-45.4%). Reductions were also similar whether women were taking combined oral contraceptives (-47.0%) or were not (-46.6%). Topiramate reduces the frequency, but not severity or duration, of perimenstrual migraines in women with MRM, i...Continue Reading

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Citations

Apr 18, 2013·Journal of General Internal Medicine·Tatyana A ShamliyanRobert L Kane
Jul 16, 2011·Expert Opinion on Drug Metabolism & Toxicology·Anna FerrariEmilio Sternieri
Oct 28, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y XiaoX Zhao
Apr 10, 2013·The Journal of Headache and Pain·Yong HuLingjing Jin
May 29, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Vincent T Martin
Dec 8, 2017·Expert Opinion on Pharmacotherapy·G AllaisChiara Benedetto
Aug 5, 2020·The Journal of Headache and Pain·Jelena M PavlovicDaniel D Mikol
Feb 19, 2021·Lancet Neurology·Kjersti Grøtta Vetvik, E Anne MacGregor
Jun 3, 2021·Journal of Clinical Medicine·Raffaele OrnelloSimona Sacco
Jun 10, 2021·Pain and Therapy·Marcello SilvestroAntonio Russo
Sep 9, 2021·Neurology·Daphne S van CasterenGisela M Terwindt

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Methods Mentioned

BETA
pregnancy
contraception

Software Mentioned

PROMPT

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