Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse-transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age

The Journal of Infectious Diseases
Ofelia A OliveroM C Poirier

Abstract

Erythrocebus patas (patas) monkeys were used to model antiretroviral (ARV) drug in human immunodeficiency virus type 1-infected pregnant women. Pregnant patas dams were given human-equivalent doses of ARVs daily during 50% of gestation. Mesenchymal cells, cultured from bone marrow of patas offspring obtained at birth and at 1 and 3 years of age, were examined for genotoxicity, including centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes. Compared with controls, statistically significant increases (P < .05) in centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes were found in mesenchymal cells from most groups of offspring at the 3 time points. Transplacental nucleoside reverse-transcriptase inhibitor exposures induced fetal genotoxicity that was persistent for 3 years.

References

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Aug 18, 2004·Toxicology and Applied Pharmacology·M C PoirierVernon E Walker
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jean-Marie PeloponeseKuan-Teh Jeang
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Citations

Apr 6, 2013·The Journal of Infectious Diseases·Isabelle André-SchmutzStéphane Blanche
Jun 21, 2014·Journal de gynécologie, obstétrique et biologie de la reproduction·Laurent MandelbrotP Morlat
Apr 30, 2013·Médecine sciences : M/S·Stéphane Blanche, Josiane Warszawski
Mar 3, 2015·Expert Opinion on Drug Safety·Jeanne SibiudeStéphane Blanche
Jul 16, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·Stéphane BlancheCohorte française ANRS-EPF
Dec 12, 2013·Clinical and Experimental Immunology·L AfranS L Rowland-Jones
May 17, 2014·Environmental and Molecular Mutagenesis·Ofelia A OliveroM C Poirier
Apr 30, 2015·The Journal of Antimicrobial Chemotherapy·C MorénG Garrabou
Apr 18, 2015·Trends in Molecular Medicine·Jay A Levy
Jul 28, 2016·Environmental and Molecular Mutagenesis·Yongmin LiuM C Poirier
Nov 3, 2015·Current Protocols in Toxicology·Kathyayini V DiviOfelia A Olivero
Feb 9, 2016·AIDS·Mira HleyhelANRS French Perinatal Cohort study Group
Mar 29, 2019·Environmental and Molecular Mutagenesis·Ofelia A Olivero
Jan 1, 2014·The Pediatric Infectious Disease Journal·Jennifer Jao, Elaine J Abrams
Dec 6, 2017·Environmental and Molecular Mutagenesis·Mira HleyhelANRS French Perinatal Cohort study Group

Related Concepts

Erythrocebus patas
Lateral Plate Mesoderm
Nucleosides
Pregnancy Complications, Infectious
Prenatal Exposure Delayed Effects
HIV-1
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Bone Marrow Stromal Cells
Birth

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