Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse-transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age

The Journal of Infectious Diseases
Ofelia A OliveroM C Poirier


Erythrocebus patas (patas) monkeys were used to model antiretroviral (ARV) drug in human immunodeficiency virus type 1-infected pregnant women. Pregnant patas dams were given human-equivalent doses of ARVs daily during 50% of gestation. Mesenchymal cells, cultured from bone marrow of patas offspring obtained at birth and at 1 and 3 years of age, were examined for genotoxicity, including centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes. Compared with controls, statistically significant increases (P < .05) in centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes were found in mesenchymal cells from most groups of offspring at the 3 time points. Transplacental nucleoside reverse-transcriptase inhibitor exposures induced fetal genotoxicity that was persistent for 3 years.


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Dec 6, 2017·Environmental and Molecular Mutagenesis·Mira HleyhelANRS French Perinatal Cohort study Group

Related Concepts

Erythrocebus patas
Lateral Plate Mesoderm
Pregnancy Complications, Infectious
Prenatal Exposure Delayed Effects
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Bone Marrow Stromal Cells

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