Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic Neurotransmission in the Striatum of C57BL/6 Mice

Biological Trace Element Research
Kyunghwa SungKisok Kim

Abstract

Although exposure to arsenic (As) induces developmental neurotoxicity, there is a lack of data regarding its specific effects on glutamatergic neurotransmission in offspring from dams exposed to As during gestation and lactation. In this study, the body weight, glutamate content, and expression of vesicular glutamate transporter 2 (VGLUT2) and metabotropic glutamate receptors mGluR2 and mGluR3 was examined in the striatum of offspring following treatment of the dams with As (10 or 100 mg/L NaAsO2 in drinking water). At postnatal day 21, body weight was decreased significantly, whereas the glutamate content in the striatum of offspring in the 100-mg/L As group were not significantly different from those in the control group. Although mGluR3 expression was not significantly different, VGLUT2 and mGluR2 expression was significantly lower in the striatum of offspring of As-exposed dams. These data indicate that altered glutamatergic neurotransmission may contribute to As-induced developmental neurotoxic effects.

References

Feb 9, 2002·The Journal of Comparative Neurology·Takeshi KanekoHiroyuki Hioki
Dec 4, 2002·Neurotoxicology and Teratology·V M RodríguezM Giordano
Jan 1, 1993·Environmental Pollution·L M Del RazoM E Cebrián
Apr 23, 2004·Trends in Neurosciences·Robert T FremeauRobert H Edwards
Nov 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diederik MoecharsR Mark Hampson
Dec 7, 2006·Epidemiology·Ondine S von EhrensteinAllan H Smith
Jun 20, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jose Alfredo MendezLouis-Eric Trudeau
Oct 31, 2008·Talanta·David G Kinniburgh, Walter Kosmus
Sep 16, 2009·Pharmacology, Biochemistry, and Behavior·Ebany J Martinez-FinleyAndrea M Allan
Apr 2, 2011·Neurotoxicology·Gail A WassermanJoseph H Graziano
May 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yaneth Castro-CoronelEsther López-Bayghen
Jul 19, 2013·Toxicology and Applied Pharmacology·Shohreh F FarzanYu Chen
May 27, 2014·Current Environmental Health Reports·Christina R Tyler, Andrea M Allan
Dec 3, 2014·Current Opinion in Pharmacology·Marianne Amalric
Mar 18, 2015·Current Drug Targets·Anna V GolubevaJohn F Cryan
Oct 30, 2015·Journal of Applied Toxicology : JAT·Chandra PrakashVijay Kumar
Jan 7, 2016·Frontiers in Neuroscience·Jan Lewerenz, Pamela Maher
Oct 19, 2017·International Journal of Epidemiology·Katherine A MoonAna Navas-Acien
Jan 18, 2018·The Journal of Clinical Investigation·Thomas SteinkellnerThomas S Hnasko
Mar 5, 2018·Biological Trace Element Research·Lalit P ChandravanshiRajendra K Shukla

❮ Previous
Next ❯

Citations

Nov 22, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Carla Garza-LombóRodrigo Franco
Aug 18, 2020·BioMed Research International·Shanshan RanShugang Li

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
X-ray

Software Mentioned

SAS
ImageJ

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.