Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: the Timoun cohort study in Guadeloupe (French West Indies)

Environmental Research
Sylvaine CordierLuc Multigner

Abstract

Perinatal exposure to endocrine-disrupting chemicals may affect thyroid hormones homeostasis and impair brain development. Chlordecone, an organochlorine insecticide widely used in the French West Indies has known estrogenic and progestin properties, but no data is available, human or animal, on its action on thyroid hormone system. Our aim was to evaluate the impact of perinatal exposure to chlordecone on the thyroid hormone system of a sample of infants from the Timoun mother-child cohort in Guadeloupe and their further neurodevelopment. Chlordecone was measured in cord blood and breast milk samples. Thyroid stimulating hormone (TSH), free tri-iodothyronine (FT3), free thyroxine (FT4) were determined in child blood at 3 months (n=111). Toddlers were further assessed at 18 months using an adapted version of the Ages and Stages Questionnaire (ASQ). Cord chlordecone was associated with an increase in TSH in boys, whereas postnatal exposure was associated with a decrease in FT3 overall, and in FT4 among girls. Higher TSH level at 3 months was positively associated with the ASQ score of fine motor development at 18 months among boys, but TSH did not modify the association between prenatal chlordecone exposure and poorer ASQ fine m...Continue Reading

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Citations

Mar 8, 2016·Journal of Molecular Graphics & Modelling·Juan José Gamboa-CarballoUlises Javier Jáuregui-Haza
May 6, 2015·Environmental Science and Pollution Research International·Luc MultignerSylvaine Cordier
Jul 14, 2016·Environmental Health : a Global Access Science Source·Vincent NedellecWilliam Dab
Aug 2, 2016·The Journal of Pediatrics·Yudan Wei, Jianmin Zhu
Jan 10, 2017·Frontiers in Microbiology·Sébastien ChaussonnerieDenis Le Paslier
Sep 30, 2018·Current Environmental Health Reports·Cécile Chevrier, Rémi Béranger
Dec 2, 2019·Environmental Science and Pollution Research International·Matthieu DelannoyCyril Feidt
Jan 11, 2020·Frontiers in Endocrinology·Michelle LeemansJean-Baptiste Fini
Dec 23, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jennifer H OlkerSigmund J Degitz
Sep 7, 2020·Environmental Toxicology and Pharmacology·Matthieu DelannoyCéline Cakir-Kiefer
Dec 7, 2019·The Science of the Total Environment·Patrick OllivierChristophe Mouvet

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