Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats

Journal of Perinatal Medicine
Shang-Qin ChenJing Lin

Abstract

Pregnant women and infants have significant exposures to the most commonly used plasticizer di-(2-ethylhexyl) phthalate (DEHP). This study was designed to evaluate the effects of DEHP exposure on growth and lung maturation in rats and determine if DEHP regulation of 11beta-hydroxysteroid dehydrogenase type 1 gene (Hsd11b1) expression in the lung tissue plays a role in its effects on lung maturation. Pregnant Sprague-Dawley rats were treated from gestational day 12 to postnatal day (PND) 21 with DEHP orally at dosages of 0, 10, 100 or 750 mg/kg/day, respectively (n=8 for each group). Two rat pups (one male and one female) from each litter were sacrificed at PND 1 and 21. Body weight was measured and the lung was processed for histology and calculation of lung interstitial tissue proportion as well as real-time PCR determination of the expressions of Hsd11b1, surfactant associated protein-A1 gene (Sftpa1) and B gene (Sftpb). The perinatal DEHP exposure led to a dose dependent intrauterine and postnatal growth restriction (P<0.001). High dose DEHP (750 mg/kg/day) exposure led to decreased gas-exchange space as evidenced by increased lung interstitial tissue proportion (P<0.001), but did not cause significant changes in Hsd11b1, Sf...Continue Reading

References

Aug 28, 2012·Epigenomics·Keith E LathamNora Engel
Apr 15, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michelle L NorthAnne K Ellis
Dec 12, 2012·Paediatric and Perinatal Epidemiology·Eleni PapadopoulouManolis Kogevinas
Oct 8, 2016·Environmental Science and Pollution Research International·Maryam ZareanRoya Kelishadi
Sep 27, 2013·The Journal of Toxicological Sciences·Shun-Sheng ChenDean-Chuan Wang
Apr 26, 2020·International Journal of Environmental Research and Public Health·W S KwanK N Yu

Citations

Dec 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L G ParksLeon Earl Gray
May 10, 2002·Nucleic Acids Research·Tony YuenStuart C Sealfon
Sep 10, 2002·Experimental Lung Research·Stefan A Tschanz, Peter H Burri
Nov 20, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S HundertmarkC Lipka
Nov 20, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S HundertmarkJ R Seckl
Dec 25, 2002·Toxicology and Applied Pharmacology·Jean S Wong, Sarjeet S Gill
Feb 5, 2003·Biology of the Neonate·Giuseppe LatiniPietro Mazzeo
Apr 2, 2003·Seminars in Neonatology : SN·Eduardo BancalariIlene R S Sosenko
Jun 13, 2003·Histochemistry and Cell Biology·Roberta MagliozziStefania Stefanini
Nov 5, 2003·Environmental Health Perspectives·Jennifer J AdibiRobin M Whyatt
Nov 5, 2003·Environmental Health Perspectives·Giuseppe LatiniPietro Mazzeo
Jan 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Benson T AkingbemiMatthew P Hardy
Mar 16, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Jane S Fisher
Apr 22, 2005·Acta Paediatrica·M De Curtis, J Rigo
Sep 6, 2005·The Journal of Toxicological Sciences·Mariko ShirotaMasanobu Katoh
Oct 27, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·R C GrastyJ M Rogers
Oct 5, 2006·Current Medicinal Chemistry·Giuseppe LatiniClaudio De Felice
Jan 30, 2007·Reproductive Toxicology·Ren-Shan GeMatthew P Hardy
Dec 8, 2007·International Journal of Pharmaceutics·Satoshi TakatoriHiroyuki Nakazawa
Feb 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andrew K HotchkissLeon Earl Gray
Apr 17, 2008·Environmental Health Perspectives·Jennifer J AdibiRuss Hauser
May 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Han LinMatthew P Hardy
Aug 19, 2008·Environmental Health Perspectives·Mary S WolffAntonia M Calafat
Dec 20, 2008·Histochemistry and Cell Biology·Barbara Rosicarelli, Stefania Stefanini
Jun 2, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Leon Earl GrayClark L Gray
Jun 27, 2009·The Journal of Pediatrics·Yunhui ZhangRen-Shan Ge

Related Concepts

Real-Time Polymerase Chain Reaction
Fetal Organ Maturity
Histology Procedure
Diethylhexyl Phthalate
Surfactant [EPC]
Endogenous Surfactants
Lung
Rat Lung
Interstitial Tissue
Weighing Patient

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.