Perinatal exposure to PTU decreases expression of Arc, Homer 1, Egr 1 and Kcna 1 in the rat cerebral cortex and hippocampus

Brain Research
Kumiko KobayashiRyozo Tsuji

Abstract

Environmental chemicals have a potential impact on neuronal development and children's health. The current developmental neurotoxicity (DNT) guideline studies to assess their underlying risk are costly and time-consuming; therefore the more efficient protocol for DNT test is needed. Hypothyroidism in rats induced by perinatal exposure to propylthiouracil (PTU), a thyroid hormone synthesis inhibitor, offers an advantageous model of developmental neurotoxicity (DNT). Understanding the associated alterations in gene expression in brain is a key to elucidate mechanisms and find appropriate molecular markers. The purpose of the present study was to identify PTU treatment-affected transcriptomes in the rat cerebral cortex and the hippocampus using DNA microarrays, and to specify candidate genes linked to DNT. We used an approximately 9000 probe microarray to examine differentially expressed genes between PTU-dosed and vehicle-dosed rats at postnatal days 4, 14, 22 and 70. Expression of immediate early genes (IEGs) such as activity-regulated cytoskeleton-associated protein (Arc), Homer 1, early growth response 1 (Egr 1), myelin-associated genes such as myelin-associated oligodendrocytic basic protein (MOBP), myelin basic protein (MBP)...Continue Reading

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Citations

Feb 11, 2012·American Journal of Physiology. Cell Physiology·Ayako MakinoWolfgang H Dillmann
Jul 19, 2011·Journal of Thyroid Research·Fabrice ChatonnetFrédéric Flamant
Sep 13, 2015·Seizure : the Journal of the British Epilepsy Association·Seyedeh Masoumeh Seyedhoseini TamijaniAbolhassan Ahmadiani
Dec 23, 2020·Neurotoxicology·Vanessa NaffaaAnne-Laure Schang

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