Perinatal exposure to xenoestrogens impairs mammary gland differentiation and modifies milk composition in Wistar rats

Reproductive Toxicology
Laura KassM Muñoz-de-Toro

Abstract

The current study examined the consequences of perinatal (gestation+lactation) exposure to Bisphenol A (BPA) or diethylstilbestrol (DES) on F1 mammary gland (MG) differentiation. BPA (0, 0.7 or 64 μg/kg bw/day) or DES (6 μg/kg bw/day) was administered in the drinking water of F0 rats from gestational day 9 (GD9) until weaning. F1 females were bred, MG samples obtained on GD18 and GD21, and, during lactation, milk yield and milk protein composition were assessed. On GD18, there was a decrease in α-lactalbumin and β-casein levels that was accompanied by reduced prolactin receptor and Stat5a/b expression. On GD21, delayed histological MG differentiation was observed. β-Casein levels remained decreased on GD21 and in milk samples. Moreover, the BPA- and DES-exposed groups had an altered milk yield pattern during lactation. The long-lasting effects of perinatal exposure to low doses of xenoestrogens included delayed MG differentiation, altered milk yield and modified milk composition.

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Citations

Dec 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Clarisa SantamaríaRodriguez A Horacio
Jun 12, 2013·General and Comparative Endocrinology·Milena DurandoMónica Muñoz-de-Toro
Feb 26, 2014·Reproductive Toxicology·Laura KassMónica Muñoz-de-Toro
Sep 3, 2013·Reproductive Toxicology·Johanna R Rochester
Oct 4, 2014·Reproductive Toxicology·Tessie PauloseAna M Soto
Aug 6, 2014·Reproductive Toxicology·Gwendolyn OsborneMegan Schwarzman
May 16, 2015·Molecular and Cellular Endocrinology·Gabriela A AltamiranoLaura Kass
Jun 25, 2013·Reproductive Toxicology·Alberto Mantovani, Aleksandra Fucic
Jun 12, 2016·Toxicology·Marlise Guerrero SchimpfJorgelina Varayoud
Jul 28, 2016·Environmental Toxicology·Jorgelina VarayoudEnrique H Luque
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Aug 20, 2018·The Journal of Endocrinology·Marlise Guerrero SchimpfJorgelina Varayoud
Apr 22, 2020·Molecular and Cellular Endocrinology·M Florencia RossettiJorge G Ramos
Oct 8, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Rachel CriswellMegan E Romano
Aug 12, 2020·Molecular and Cellular Endocrinology·Bracho Gisela SBosquiazzo Véronica L

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