Perinatal expression of IGFBPs in rat lung and its hormonal regulation in fetal lung explants

The American Journal of Physiology
J K van de WeteringJ J Batenburg

Abstract

To gain more insight into the regulation of the expression of insulin-like growth factor (IGF) binding proteins (IGFBPs) in the lung, the developmental patterns of the abundance of the mRNAs encoding IGFBPs were measured in the perinatal rat lung and in explant cultures of fetal rat lung. In hormone-free explant cultures, the levels of the mRNAs encoding IGFBP-2 through -5 changed with a pattern similar to that occurring in vivo (although in the case of IGFBP-3 to -5 at a faster rate), indicating that the developmental regulation of the expression of these IGFBPs in perinatal lung is mimicked in the explants. For the IGFBP-6 mRNA level, the pattern in vitro differed from that in vivo. In the explant cultures, dexamethasone decreased the production of IGFBP-3 and -4 and decreased the abundance of the mRNAs encoding IGFBP-2 to -5 but increased the abundance of IGFBP-6 mRNA. These observations indicate that glucocorticoids may be involved in the developmental regulation of the expression of these components of the IGF system and that the IGF system may be involved in the physiological effects of glucocorticoids on lung development. No appreciable effects of 3,3',5-triiodothyronine on the expression of the IGFBPs were observed.

References

Jul 1, 1991·Molecular Endocrinology·S ShimasakiN Ling
Sep 1, 1991·Pediatric Research·A Noguchi, T Nelson
Jan 15, 1991·The Biochemical Journal·T E Weaver, J A Whitsett
Jul 1, 1989·American Journal of Respiratory Cell and Molecular Biology·A D Stiles, B M Moats-Staats
Jan 1, 1995·American Journal of Respiratory Cell and Molecular Biology·B M Moats-StaatsA D Stiles
Aug 1, 1994·Molecular and Cellular Endocrinology·A G SchullerS L Drop
Jan 1, 1993·Vitamins and Hormones·M M Rechler
Apr 1, 1993·American Journal of Respiratory Cell and Molecular Biology·W A PriceA D Stiles
Jan 1, 1994·Annual Review of Physiology·P Minoo, R J King
Jan 1, 1996·American Journal of Respiratory Cell and Molecular Biology·G Z Retsch-BogartA D Stiles

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Citations

Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·G A BraemsF Possmayer
Jun 14, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yang WangLin Liu

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