Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
R C KoehlerLee J Martin

Abstract

Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our understanding of cellular mechanisms of neural injury in developing brain, but have limitations in simulating the range, accuracy, and physiology of clinical hypoxia-ischemia and the relevant systems neuropathology that contribute to the human brain injury pattern. Large animal models of perinatal hypoxia-ischemia, such as partial or complete asphyxia at the time of delivery of fetal monkeys, umbilical cord occlusion and cerebral hypoperfusion at different stages of gestation in fetal sheep, and severe hypoxia and hypoperfusion in newborn piglets, have largely overcome these limitations. In monkey, complete asphyxia produces preferential injury to cerebellum and primary sensory nuclei in brainstem and thalamus, whereas partial asphyxia produces preferential injury to somatosensory and motor cortex, basal ganglia, and thalamus. Mid-gestational fetal sheep provide a valuable model for studying vulnerability of progenitor oligodendrocytes. Hypoxia followed by asphyxia in newborn piglets replicates the systems injury seen in term newborns. Efficacy of post-insult ...Continue Reading

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Citations

Dec 1, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eng H Lo, Michael A Moskowitz
Feb 16, 2020·Journal of Neuroscience Research·Clémence Disdier, Barbara S Stonestreet
Jun 11, 2019·Frontiers in Physiology·Maryam ArdalanCarina Mallard
Nov 14, 2019·Neural Regeneration Research·Hamid Abbasi, Charles P Unsworth
May 22, 2020·Frontiers in Cellular Neuroscience·Laura Poupon-BejuitAhad A Rahim
Oct 30, 2020·Frontiers in Neuroscience·Xiaotong ZhangXiaomin Zhang
Jun 3, 2021·International Journal of Molecular Sciences·Raymand PangNicola J Robertson
Jul 23, 2021·Nature Reviews. Neuroscience·Stefano G DanieleNenad Sestan
Jul 22, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul J RozanceLaura D Brown
Dec 11, 2020·Developmental Neuroscience·Bing WangZeng-Jin Yang

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