PMID: 18424604Apr 22, 2008Paper

Perinatal iron deficiency affects locomotor behavior and water maze performance in adult male and female rats

The Journal of Nutrition
Stephane L BourqueKanji Nakatsu

Abstract

Iron deficiency during early growth and development adversely affects multiple facets of cognition and behavior in adult rats. The purpose of this study was to assess the nature of the learning and locomotor behavioral deficits observed in male and female rats in the absence of depressed brain iron levels at the time of testing. Adult female Wistar rats were fed either an iron-enriched diet (>225 mg/kg Fe) or an iron-restricted diet (3 mg/kg Fe) for 2 wk prior to and throughout gestation, and a nonpurified diet (270 mg/kg Fe) thereafter. Open-field (OF) and Morris water maze (MWM) testing began when the offspring reached early adulthood (12 wk). At birth, perinatal iron-deficient (PID) offspring had reduced (P < 0.001) hematocrits (-33%), liver iron stores (-83%), and brain iron concentrations (-38%) compared with controls. Although there were no differences in iron status in adults, the PID males and females exhibited reduced OF exploratory behavior, albeit only PID males had an aversion to the center of the apparatus (2.5 vs. 6.9% in controls, P < 0.001). Additionally, PID males required greater path lengths to reach the hidden platform in the MWM, had reduced spatial bias for the target quadrant, and had a tendency for great...Continue Reading

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Citations

Oct 6, 2009·The Journal of Veterinary Medical Science·Zhixiong HeZhiliang Tan
Mar 23, 2017·Neurotoxicity Research·Vasanth DhakshinamoorthyEkambaram Perumal
Mar 24, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ellis NelissenTim Vanmierlo
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