Perinatal neuroendocrine regulation. Development of the circadian time-keeping system

Molecular and Cellular Endocrinology
María Serón-FerréGuillermo J Valenzuela

Abstract

During gestation, the perinatal neuroendocrine axis keeps clock time. In primates, the suprachiasmatic nucleus (biological clock in mammals), shows oscillatory function by midgestation. There is evidence in rodents that the mother, during pregnancy, entrains the fetal suprachiasmatic nucleus (SCN) and newborn circadian rhythms. We are investigating the role of maternal melatonin as an entraining signal for the newborn circadian time-keeping system in the Cebus apella (New World non-human primate). Twenty-four hour rhythms of temperature and cortisol are present in the 4 days old C. apella newborn. Preliminary data suggests that inhibition of maternal melatonin by exposing pregnant females to constant light alters these rhythms. We have found binding sites for melatonin and expression of mRNA for Mel 1A receptor in hypothalamus, kidney and testis. These preliminary results suggest that maternal melatonin may play a role in relating the perinatal circadian time-keeping system to environmental signals.

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Citations

Mar 2, 2010·Journal of Molecular Neuroscience : MN·Lauren A Segall, Shimon Amir
Nov 17, 2006·Reproduction, Nutrition, Development·Lissia Pardini, Bertrand Kaeffer
Nov 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melissa SuterKjersti Aagaard-Tillery
Feb 2, 2006·In Vitro Cellular & Developmental Biology. Animal·Bertrand Kaeffer, Lissia Pardini
Jul 25, 2007·Journal of Pineal Research·Cyril D TomaTheresia Thalhammer
Mar 7, 2006·Early Human Development·Yuri MaedaTsuyoshi Iwasaka
Feb 16, 2016·Scientific Reports·Yosuke KaneshiHisanori Minakami
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Claudia Torres-FarfanMaría Serón-Ferré
May 5, 2011·Chronobiology International·Matilde Zornoza-MorenoJuan Antonio Madrid
Oct 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Jonneke J HollandersMartijn J J Finken
Apr 9, 2020·Biology·Dmitry O IvanovRuslan A Nasyrov
Apr 3, 2020·International Journal of Molecular Sciences·Claus Behn, Nicole De Gregorio
Jul 19, 2005·Chronobiology International·Dietmar Weinert
Jul 28, 2016·Sleep and Biological Rhythms·Karen A ThomasSusan Spieker

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