Perinatal outcomes and intrauterine complications following fetal intervention for congenital heart disease: systematic review and meta-analysis of observational studies

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
E Araujo JúniorW P Martins

Abstract

To assess perinatal outcomes and intrauterine complications following fetal intervention for congenital heart disease (CHD). A systematic review and meta-analysis were performed following an electronic search of PubMed and Scopus databases (last searched August 2015). Perinatal outcomes that were assessed included fetal death, live birth, preterm delivery < 37 weeks' gestation and neonatal death. Intrauterine complications that were assessed included bradycardia requiring treatment and hemopericardium requiring drainage. Estimated proportions were reported as mean (95% CI). Inconsistency was assessed using the I(2) statistic. An electronic search identified 2279 records, of which 29 studies (11 retrospective cohort and 18 case reports) were considered eligible for analysis. Fetal death after treatment of CHD by aortic valvuloplasty was reported in three studies, with a rate of 31% (95% CI, 9-60%), after pulmonary valvuloplasty in one study, with a rate of 25% (95% CI, 10-49%), after septoplasty in one study, with a rate of 14% (95% CI, 6-28%) and after pericardiocentesis and/or pericardioamniotic shunt placement in 24 studies, with a rate of 29% (95% CI, 18-41%). Bradycardia requiring treatment was reported after aortic valvulo...Continue Reading

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Citations

Aug 16, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Marla B FerschlYehuda Ginosar
Oct 19, 2017·Korean journal of pediatrics·Seong-Ho Kim
Dec 21, 2019·Biological Reviews of the Cambridge Philosophical Society·Warren BurggrenTobias Wang
Feb 16, 2017·Current Treatment Options in Cardiovascular Medicine·Caroline K Lee

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