Perinatal outcomes in a subsequent pregnancy among women who have experienced recurrent miscarriage: a retrospective cohort study

Human Reproduction
K Field, D J Murphy

Abstract

Is a history of three or more miscarriages associated with adverse perinatal outcomes in a subsequent pregnancy? Recurrent miscarriage is associated with an increased risk of adverse perinatal outcomes, including preterm birth, very preterm birth and perinatal death, in a subsequent pregnancy. Published data are conflicting with some studies reporting an increase in adverse perinatal outcomes in association with prior recurrent miscarriage while others report little or no increase. Large-scale population-based studies have been lacking. We performed a retrospective cohort study of 30 053 women with a singleton pregnancy who booked for antenatal care and delivery between January 2008 and July 2011. All women who attended a university affiliated hospital in Ireland had a detailed obstetric history taken, recording the outcome of all previous pregnancies. We compared the obstetric and perinatal outcomes of 2030 women (6.8%) who had a history of three or more miscarriages (recurrent miscarriage) with the outcomes of 28 023 women (93.2%) who did not. Logistic regression analyses were performed, adjusting for potential confounding factors. Women with a history of recurrent miscarriage were more likely to be obese, to have undergone a...Continue Reading

References

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Citations

Jan 23, 2016·Archives of Gynecology and Obstetrics·Christiane KlingDieter Kabelitz
Jan 5, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Meertien K SijpkensAgeeth N Rosman
Mar 22, 2019·BMJ : British Medical Journal·Maria C MagnusSiri E Håberg
Feb 7, 2020·PloS One·Julian K Christians, Maria F Huicochea Munoz
Oct 22, 2017·Acta Obstetricia Et Gynecologica Scandinavica·Marise M WagnerKitty W M Bloemenkamp
Sep 5, 2020·Journal of Clinical Medicine·Carlo TicconiNicoletta Di Simone
Jul 1, 2020·American Journal of Perinatology·Elizabeth B AusbeckLorie Harper
Dec 12, 2020·Nature Reviews. Disease Primers·Evdokia DimitriadisJan J Brosens
Dec 17, 2020·International Journal of Women's Health·Nasloon AliLuai A Ahmed
Jul 4, 2021·Tissue & Cell·Carlo TicconiAsgerally Fazleabas
Aug 8, 2021·American Journal of Reproductive Immunology : AJRI·Aera HanKi Hwan Lee

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