Perinatal profile of ventricular overload markers in congenital diaphragmatic hernia

Journal of Pediatric Surgery
Maria João BaptistaJorge Correia-Pinto

Abstract

In congenital diaphragmatic hernia (CDH), pulmonary hypertension increases right ventricle (RV) afterload, which could impair heart function and contribute to poor outcome for most affected infants. Nevertheless, the real significance of vascular pulmonary alterations in perinatal hemodynamics is largely unknown. It is defined that ventricular pressure overload induces increased myocardium gene expression of B-type natriuretic peptide (BNP) and components of the renin-angiotensinogen and endothelin (ET)-1 systems. Our aim was to evaluate perinatal myocardium expression of these genes associated with ventricular pressure overload in a nitrofen-induced CDH rat model. In the nitrofen-induced CDH rat model, fetuses from dated pregnant Sprague-Dawley rats at 15.5, 17.5, 19.5 and 21.5 days postcoitum as well as newborn pups were assigned to 3 experimental groups: control, nitrofen (exposed to nitrofen, without CDH), and CDH (exposed to nitrofen, with CDH). Myocardial samples collected from the RV and left ventricle (LV) were processed for quantification of messenger RNA (mRNA) of BNP, angiotensinogen, and ET-1. The perinatal expression of BNP, angiotensinogen, and ET-1 mRNA in the RV and LV of the control group revealed daily changes...Continue Reading

References

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Citations

Nov 25, 2011·Molecular Medicine·Cristina Nogueira-SilvaJorge Correia-Pinto
Jul 25, 2009·Acta Paediatrica·S Grisaru-GranovskyM S Schimmel
Oct 11, 2019·American Journal of Respiratory and Critical Care Medicine·David G Tingay, John P Kinsella
Feb 14, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aline VuckovicJacques C Jani
Apr 10, 2018·The Journal of Pediatrics·John P KinsellaUNKNOWN Pediatric Pulmonary Hypertension Network (PPHNet)

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