Perinatal risk-indicators for long-term respiratory morbidity among preterm or very low birth weight neonates

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Margreet J TeuneDutch POPS Collaborative Study Group

Abstract

To develop prediction models for long-term respiratory morbidity. To explore if respiratory distress syndrome (RDS) is a risk-indicator for long-term respiratory morbidity and to identify other perinatal risk-indicators for long-term respiratory morbidity. In the Dutch POPS cohort 1338 live born infants delivered in The Netherlands in 1983, either before 32 completed weeks gestation and/or with a birth weight below 1500 g, were followed prospectively. We used multivariable logistic regression analyses to construct three prediction models for respiratory morbidity at 2, 5 and 19 years of age. At 2 years of age, maternal smoking (adjusted OR 1.5, 95% CI 1.0-2.4), prolonged rupture of membranes (adjusted OR 2.3, 95% CI 1.3-4.1), pre-eclampsia (adjusted OR 1.9, 95% CI 1.1-4.1), male gender (adjusted OR 1.5, 95% CI 1.1-2.0) and BPD (adjusted OR 1.9, 95% CI 1.1-3.2) were significantly associated with respiratory morbidity. Prolonged rupture of membranes (adjusted OR 3.7, 95% CI 1.6-8.5), family history of asthma (adjusted OR 5.9, 95% CI 2.7-13.0) and BPD (adjusted OR 1.8, 95% CI 1.1-3.0) were significantly associated with respiratory morbidity at 5 years of age. At 19 years of age only higher social class was associated with decrease...Continue Reading

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Citations

Feb 20, 2013·Archives of Gynecology and Obstetrics·Zarqa AliDorthe Lisbeth Jeppesen
Jul 27, 2015·Journal of Biomedical Informatics·John Wes Solomon, Rodney D Nielsen
Jun 25, 2013·American Journal of Obstetrics and Gynecology·Gert-Jan van BaarenBen W Mol
Aug 17, 2010·Early Human Development·Jennifer B HeldermanT Michael O'Shea
Apr 4, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G-J van BaarenB W J Mol
Aug 31, 2018·Pediatric Pulmonology·Wesley M JacksonAlan Leviton

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