Perinatal substance use: a prospective evaluation of abstinence and relapse

Drug and Alcohol Dependence
Ariadna ForrayKimberly A Yonkers

Abstract

Substance use decreases in pregnancy but little prospective data are available on the rates of abstinence and relapse for specific substances. This study compared rates of abstinence in pregnancy and relapse postpartum for nicotine cigarettes, alcohol, marijuana, and cocaine. Data from 152 women drawn from a randomized controlled trial comparing psychological treatments for substance use in pregnancy were analyzed. Self-reports of substance use and urine for toxicology testing throughout pregnancy and 3-months, 12-months and 24-months post-delivery were collected. Multivariate Cox models were used to compare rates of abstinence and relapse across substances. In pregnancy, 83% of all women achieved abstinence to at least one substance. The mean (SE) days to abstinence was 145.81 (9.17), 132.01 (6.17), 151.52 (6.24), and 148.91 (7.68) for cigarettes, alcohol, marijuana and cocaine, respectively. Participants were more likely to achieve abstinence from alcohol (HR 7.24; 95% CI 4.47-11.72), marijuana (HR 4.06; 95% CI 1.87-6.22), and cocaine (HR 3.41; 95% CI 2.53-6.51), than cigarettes. Postpartum, 80% of women abstinent in the last month of pregnancy relapsed to at least one substance. The mean days to relapse was 109.67 (26.34), 1...Continue Reading

References

Jan 1, 1992·Journal of Substance Abuse Treatment·A T McLellanM Argeriou
May 1, 1996·Psychological Medicine·A J RushM H Trivedi
Oct 1, 1996·American Journal of Public Health·M RussellJ Jacobson
Nov 1, 1996·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·L D GilchristD M Morrison
Jul 1, 1997·Obstetrics and Gynecology·E Hutchins, J DiPietro
Aug 6, 1992·Health Education Research·C M McBrideS J Curry
Apr 9, 1999·Journal of Substance Abuse Treatment·E M HowellM Harrington
Jun 17, 1999·Journal of Studies on Alcohol·G ChangM A Goetz
Sep 13, 2000·Tobacco Control·C C DiClementeR A Windsor
Jan 30, 2003·American Journal of Preventive Medicine·Gregory J Colman, Ted Joyce
Feb 11, 2003·Obstetrics and Gynecology·Shahul H Ebrahim, Joseph Gfroerer
May 6, 2003·Health Education Research·C M McBrideI M Lipkus
Jun 19, 2004·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sven Cnattingius
Oct 27, 2004·Addiction·Madhabika Beverta Nayak, Lee Ann Kaskutas
May 21, 2005·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Robyn KennareAnnabelle Chan
Sep 15, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Jennifer Prah RugerKaren M Emmons
Oct 26, 2007·Journal of Studies on Alcohol and Drugs·Tanya Jagodzinski, Michael F Fleming
Jun 7, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Akiyo KanekoTakashi Ohida
Jul 10, 2008·Journal of Studies on Alcohol and Drugs·Heather A Flynn, Stephen T Chermack
Sep 10, 2008·Drug and Alcohol Dependence·Jennifer R HavensWendy F Hansen
Sep 10, 2008·American Journal of Preventive Medicine·Van T TongLisa A Asare
May 14, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Elyse R ParkNancy Rigotti
Feb 16, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Lorraine R ReitzelDavid W Wetter
Feb 23, 2010·Drug and Alcohol Dependence·Marleen M H J van GelderUNKNOWN National Birth Defects Prevention Study
Mar 4, 2011·Maternal and Child Health Journal·M Elizabeth GyllstromDeborah Hennrikus
Jul 24, 2013·The Journal of Obstetrics and Gynaecology Research·Takako YasudaZentaro Yamagata
Oct 8, 2013·Drug and Alcohol Dependence·Megan E PasseyJanelle M Stirling

❮ Previous
Next ❯

Citations

Sep 21, 2015·Current Psychiatry Reports·Ariadna Forray, Dawn Foster
Aug 8, 2015·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Cecilia L Bergeria, Sarah H Heil
Jun 28, 2016·Neurotoxicology and Teratology·Olivier J BarthelemyDeborah A Frank
Oct 30, 2016·American Journal of Obstetrics and Gynecology·Tricia E WrightAndreea A Creanga
Dec 2, 2017·Reviews in the Neurosciences·Anna Brancato, Carla Cannizzaro
Jan 18, 2018·Fundamental & Clinical Pharmacology·Liselotte PochardUNKNOWN French Addictovigilance Network
Jul 12, 2018·Obstetrics and Gynecology·Davida M SchiffThomas Land
Jun 5, 2018·Journal of Addiction Medicine·Yukiko WashioMishka Terplan
May 31, 2016·F1000Research·Ariadna Forray
May 15, 2019·Obstetrics and Gynecology·Marcela C SmidErin A S Clark
Sep 11, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Cynara M PereiraJosé G Cecatti
Nov 7, 2019·Journal of Addiction Medicine·Kelly C Young-WolffStacey Alexeeff
Nov 5, 2019·Research on Social Work Practice·Danielle E ParrishMary M Velasquez
Jul 13, 2018·Obstetric Medicine·Kerry-Ann Louw
May 29, 2019·Obstetrics and Gynecology·Marcela C SmidErin A S Clark
May 28, 2020·Obstetrics and Gynecology·David M HaasGeorge R Saade
May 4, 2020·Journal of Substance Abuse Treatment·Kimberly A YonkersSteve Martino
Dec 17, 2017·American Journal of Obstetrics and Gynecology·Steve MartinoKimberly A Yonkers
Apr 13, 2021·American Journal of Obstetrics and Gynecology·Davida M SchiffTimothy E Wilens
Sep 3, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ann M BrunoTorri D Metz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.