PMID: 15220695Jun 29, 2004Paper

Perinatal transmission and viral evolution of hepatitis C virus quasispecies in infants coinfected with HIV

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Henry PollackWilliam Borkowsky

Abstract

Three HIV/hepatitis C virus (HCV)-coinfected children and the mothers of 2 were studied to examine the nature of perinatal HCV infection in HIV-coinfected infants and to assess the evolution of viral quasispecies thereafter. Sequences of the hypervariable region in the N terminus of the E2/NS1 region (HVR-1) of the children and their mothers were compared. HCV quasispecies changes in the infants were tracked over several years. Sequence similarity comparisons and phylogenetic trees were derived from cDNA of plasma isolates. Quantitation of plasma HCV and HIV was performed in the children, as well as CD4 T-cell percentage and liver transaminases. Phylogenetic analysis of the mother-child pairs suggested that transmission of multiple dominant and nondominant variants identified in the mother were seen. HCV diversification in the children was seen as early as 2 months of life. The child with the best immune status and HIV control demonstrated the most diversification throughout. Multiples HCV variants transmitted from mother to child and their early changes in the child may be related to maternal antibody. Variation after the 1st year of life may reflect immunologic pressure from the child. There was no trend suggesting that the p...Continue Reading

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Citations

Mar 16, 2005·Journal of Virology·Belinda L HerringEric L Delwart
Dec 12, 2012·Viruses·Armelle Le CampionHugo Soudeyns
May 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Patrizia FarciPier-Angelo Tovo
Aug 19, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mathieu Quesnel-VallièresHugo Soudeyns
Jan 29, 2016·World Journal of Gastroenterology : WJG·Pier-Angelo TovoSilvia Garazzino

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