Perinatal Transmission of Hepatitis C Virus: Defining the Cascade of Care

The Journal of Pediatrics
Rachel L EpsteinBenjamin P Linas

Abstract

The US National Viral Hepatitis Action Plan calls for major efforts to expand hepatitis C virus (HCV) diagnosis and treatment; prenatal care settings are potential venues for expanding HCV testing. We aimed to characterize the HCV diagnostic cascade for women and infants and investigate factors associated with linkage and follow-up. We used electronic health records for a 10-year cohort of 879 women with opioid use disorder from an obstetric clinic serving women with substance use disorders. Altogether, 744 women (85%) were screened for HCV; 510 (68%) were seropositive, of whom 369 (72%) had nucleic acid testing performed and of these 261 (71%) were viremic. Of 404 infants born to HCV-seropositive women, 273 (68%) were tested at least once for HCV, 180 (45%) completed the American Academy of Pediatrics-recommended perinatal HCV screening, and 5 (2.8%) were diagnosed with HCV infection and linked to care. More recent delivery date (2014-2015) was associated with maternal linkage to care (aOR, 2.5; 95% CI, 1.4-4.7). Maternal coinfection with HIV (aOR, 9.0; 95% CI, 1.1-72.8) and methadone maintenance therapy, compared with buprenorphine (aOR, 1.5; 95% CI, 0.9-2.5), were associated with higher rates of infant HCV testing. HCV preva...Continue Reading

Citations

Mar 8, 2019·Current Opinion in Gastroenterology·John Bian, Andrew D Schreiner
Dec 10, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN AASLD-IDSA Hepatitis C Guidance Panel
Jul 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charitha GowdaJonathan R Honegger
Oct 19, 2019·AJNR. American Journal of Neuroradiology·S L MerharB Kline-Fath
Jan 9, 2019·Hepatology Communications·Tatyana Kushner, Norah A Terrault
Oct 17, 2019·Journal of the Pediatric Infectious Diseases Society·Chase Perfect, Ravi Jhaveri
Apr 16, 2019·Therapeutic Advances in Infectious Disease·Tatyana KushnerNancy Reau
Aug 23, 2020·Journal of Pediatric Gastroenterology and Nutrition·Daniel H LeungShikha S Sundaram
Feb 12, 2020·American Journal of Obstetrics and Gynecology·Sammy SaabPrabhu Gounder
May 25, 2020·The Journal of Pediatrics·James E Squires, William F Balistreri
Apr 9, 2021·World Journal of Gastroenterology : WJG·Michael Evan Rogers, William F Balistreri
Mar 21, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ravi JhaveriSeema K Shah
May 26, 2021·Clinics in Perinatology·Rachel L Epstein, Claudia Espinosa
Jul 10, 2021·World Journal of Gastroenterology : WJG·Ângelo Zambam de MattosAngelo Alves de Mattos
May 28, 2019·Delaware Journal of Public Health·Stephen C Eppes
Feb 16, 2020·Pediatrics·Susan M LopataStephen W Patrick

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