PMID: 8947949Nov 1, 1996Paper

Perinatal treatment of rats with opiates affects the development of the blood-brain barrier transport system PTS-1

Neurotoxicology and Teratology
W A BanksJ E Zadina

Abstract

Previous results have shown that treatment of rats with morphine during the neonatal period can influence development of peptide transport system-1 (PTS-1), the blood-brain barrier transport system for Tyr-MIF-1 and methionine enkephalin. Previous work has suggested that the activity level of PTS-1 correlates with the concentration of methionine enkephalin in the brain. We show here that rats treated peripherally with morphine sulfate (MS) in both the prenatal and neonatal periods have enhanced activity of PTS-1. The degree of enhancement increases with age to reach a 66% increase in comparison with controls at age 9 weeks. The mu agonist MS was more powerful than the kappa agonist ethylketocyclazocine (EKC) or the delta agonist [D-Pen2.5,pCl-Phe4]enkephalin (pCl-DPDPE) in producing this effect. Opiate antagonists had complex effects with methylnaltrexone blocking the action of MS on PTS-1. These results show that the level of PTS-1 activity in adult rats can be modified by perinatal events that affect opiate tone during development.

References

May 1, 1991·Neuroendocrinology·D A DurhamA J Kastin
Dec 1, 1989·Brain Research Bulletin·W A BanksD A Durham
Apr 1, 1967·Brain Research·B L Wise, D R Taxdal
Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·R C HemmerR D Olson
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·M Bianchi, A E Panerai
Oct 1, 1993·Reviews in the Neurosciences·W A Banks, A J Kastin

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Citations

Nov 14, 2002·Neurotoxicology·Mona ThiruchelvamDeborah A Cory-Slechta
Jan 1, 1997·Peptides·G A OlsonA J Kastin
Aug 8, 2001·Brain Research Bulletin·I S ZagonP J McLaughlin
Apr 4, 2002·Alimentary Pharmacology & Therapeutics·A J WakefieldS H Murch
Jan 25, 2013·Pharmacological Reviews·Patrick T Ronaldson, Thomas P Davis
May 27, 2008·Brain, Behavior, and Immunity·Jessica L Lynch, William A Banks
Mar 1, 2003·Nutritional Neuroscience·K L Reichelt, A M Knivsberg
Sep 6, 2002·Autism : the International Journal of Research and Practice·K M SolaasK L Reichelt
Nov 9, 2007·Peptides·Weihong Pan, Abba J Kastin

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