Perindopril. A review of its pharmacological properties and therapeutic use in cardiovascular disorders

Drugs
P A Todd, A Fitton

Abstract

Perindopril is a long acting angiotensin converting enzyme (ACE) inhibitor, which displays similar pharmacodynamic properties to other agents in this class. In common with enalapril, it is also a prodrug. After absorption, perindopril is hydrolysed to the active metabolite, perindoprilat, and with once daily administration adequate 24-hour inhibition of ACE is obtained. Perindopril 4 to 8mg once daily is usually effective for blood pressure control in patients with mild to moderate essential hypertension. Those patients who do not respond adequately to monotherapy with perindopril usually respond with the addition of a second agent, such as a thiazide diuretic. General practice trials indicate that perindopril is at least as effective and as well tolerated as usual therapeutic dosages of captopril, atenolol or hydrochlorothiazide plus amiloride in mild to moderate essential hypertension. Preliminary results indicate that perindopril may also be effective in patients with severe hypertension or congestive heart failure. Perindopril is generally well tolerated and has an adverse effect profile similar to that of other ACE inhibitors. It further clinical experience confirms initial findings, perindopril is likely to represent a us...Continue Reading

Citations

Mar 25, 2008·Therapeutics and Clinical Risk Management·Sarah N HilmerDavid G Le Couteur
Sep 2, 2015·Expert Opinion on Pharmacotherapy·William J Elliott
Jan 1, 1992·Clinical and Experimental Pharmacology & Physiology. Supplement·K R LeesJ L Reid
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·Y Yang, G J Macdonald
Sep 21, 2002·Current Medical Research and Opinion·Marcelo MasuellPedro Forcada
Dec 24, 2005·Expert Opinion on Pharmacotherapy·K Alfakih, A S Hall
Sep 6, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Matt Shirley, Paul L McCormack
Oct 27, 2017·Expert Opinion on Drug Safety·William J Elliott, Evgeny A Bistrika
Jun 12, 2001·Drugs·M Hurst, B Jarvis
Dec 18, 2003·British Journal of Clinical Pharmacology·Arduino A Mangoni, S H D Jackson
Aug 3, 2004·Journal of Clinical Pharmacology·S G Chrysant, George S Chrysant
May 23, 2006·Rapid Communications in Mass Spectrometry : RCM·Ramakrishna V S NirogiPrashanth Komarneni
May 16, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Naif AljuhaniMemy H Hassan

Related Concepts

Angiotensin-Converting Enzyme Inhibitors
Metazoa
Cardiovascular Diseases
Indoles
Perstarium

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.